SOAT1 Antibody (D-1): sc-137013
- SOAT1 Antibody (D-1) is a mouse monoclonal IgG1 κ SOAT1 antibody provided at 200 µg/ml
- raised against amino acids 1-125 of SOAT1 of human origin
- SOAT1 Antibody (D-1) is recommended for detection of SOAT1 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-SOAT1 Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for SOAT1 Antibody (D-1) for WB and IHC(P) applications. This reagent is now offered in a bundle with SOAT1 Antibody (D-1) (see ordering information below).
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SOAT1 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects SOAT1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SOAT1 (D-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SOAT1 protein, also known as sterol O-acyltransferase-1 or ACAT1, plays a crucial role in lipid metabolism by catalyzing the conversion of cholesterol and long-chain fatty acyl-coenzyme A into cholesterol esters, which are essential for maintaining cellular cholesterol homeostasis. This enzymatic activity is particularly important in atherosclerosis, contributing to foam cell formation, a key event in atherosclerotic plaque development. Human SOAT1 gene is located on chromosome 1 and is predominantly expressed in the endoplasmic reticulum of various tissues, including liver, kidney, adrenal glands, and macrophages. SOAT1 activity regulation is vital for preventing excessive cholesterol accumulation, and several inhibitors targeting SOAT1 have been developed as potential therapeutic agents for atherosclerosis. Additionally, SOAT2, another member of the SOAT family, is involved in lipoprotein assembly and cholesterol esterification in intestinal cells, highlighting the interconnected roles of these enzymes in lipid metabolism and cardiovascular health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SOAT1 Antibody (D-1) References:
- Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis. | Geng, F., et al. 2016. Clin Cancer Res. 22: 5337-5348. PMID: 27281560
- SOAT1 methylation is associated with coronary heart disease. | Abuzhalihan, J., et al. 2019. Lipids Health Dis. 18: 192. PMID: 31684966
- Circ-Tulp4 promotes β-cell adaptation to lipotoxicity by regulating soat1 expression. | Wu, L., et al. 2020. J Mol Endocrinol. 65: 149-161. PMID: 33064661
- Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer. | Liu, Y., et al. 2021. Prostaglandins Other Lipid Mediat. 153: 106537. PMID: 33454379
- Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer. | Xu, H., et al. 2021. Cell Death Discov. 7: 38. PMID: 33637695
- Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma. | Chen, Y., et al. 2021. BMC Cancer. 21: 615. PMID: 34039309
- Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis. | Ren, M., et al. 2021. Cell Death Discov. 7: 125. PMID: 34052835
- SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis. | Zhu, T., et al. 2021. Front Pharmacol. 12: 769647. PMID: 34790132
- piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure. | Zhong, N., et al. 2022. Aging (Albany NY). 14: 2678-2694. PMID: 35354120
- ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia. | Li, H., et al. 2023. Int J Mol Sci. 24: PMID: 36982689
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SOAT1 Antibody (D-1) | sc-137013 | 200 µg/ml | $316.00 | |||
SOAT1 Antibody (D-1): m-IgG1 BP-HRP Bundle | sc-531670 | 200 µg Ab; 20 µg BP | $354.00 | |||
SOAT1 Antibody (D-1) AC | sc-137013 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SOAT1 Antibody (D-1) HRP | sc-137013 HRP | 200 µg/ml | $316.00 | |||
SOAT1 Antibody (D-1) FITC | sc-137013 FITC | 200 µg/ml | $330.00 | |||
SOAT1 Antibody (D-1) PE | sc-137013 PE | 200 µg/ml | $343.00 | |||
SOAT1 Antibody (D-1) Alexa Fluor® 488 | sc-137013 AF488 | 200 µg/ml | $357.00 | |||
SOAT1 Antibody (D-1) Alexa Fluor® 546 | sc-137013 AF546 | 200 µg/ml | $357.00 | |||
SOAT1 Antibody (D-1) Alexa Fluor® 594 | sc-137013 AF594 | 200 µg/ml | $357.00 | |||
SOAT1 Antibody (D-1) Alexa Fluor® 647 | sc-137013 AF647 | 200 µg/ml | $357.00 | |||
SOAT1 Antibody (D-1) Alexa Fluor® 680 | sc-137013 AF680 | 200 µg/ml | $357.00 | |||
SOAT1 Antibody (D-1) Alexa Fluor® 790 | sc-137013 AF790 | 200 µg/ml | $357.00 |