Molecular structure of SNC 162, CAS Number: 178803-51-5
SNC 162 (CAS 178803-51-5)
Alternate Names:
4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
Application:
SNC 162 is a selective non-peptidic DOR (δ-opioid receptor) agonist
CAS Number:
178803-51-5
Molecular Weight:
419.61
Molecular Formula:
C27H37N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SNC 162 is a potent and selective non-peptide DOR (δ-opioid receptor) agonist (Ki = 0.63 nM). SNC 162 shows > 8000-fold selectivity over μ-opioid receptors.
SNC 162 (CAS 178803-51-5) References
- Discriminative stimulus effects of the nonpeptidic delta-opioid agonist SNC80 in rhesus monkeys. | Brandt, MR., et al. 1999. J Pharmacol Exp Ther. 290: 1157-64. PMID: 10454490
- Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity. | Brandt, MR., et al. 2001. J Pharmacol Exp Ther. 296: 939-46. PMID: 11181927
- Studies of tolerance and dependence with the delta-opioid agonist SNC80 in rhesus monkeys responding under a schedule of food presentation. | Brandt, MR., et al. 2001. J Pharmacol Exp Ther. 299: 629-37. PMID: 11602675
- Delta opioid discrimination learning in the rat: assessment with the selective delta agonist SNC80. | Stevenson, GW., et al. 2002. Pharmacol Biochem Behav. 71: 283-92. PMID: 11812534
- Activation of Δ-opioid receptors inhibits L-type Ca(2+) current and transient outward K(+) current in rat ventricular myocytes. | Lin, YY., et al. 2008. Sheng Li Xue Bao. 60: 38-42. PMID: 18288356
- Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics. | Banks, ML., et al. 2010. Pharmacol Biochem Behav. 97: 205-12. PMID: 20678514
- Opioid receptors and the discriminative stimulus effects of ethanol in squirrel monkeys: Mu and delta opioid receptor mechanisms. | Platt, DM. and Bano, KM. 2011. Eur J Pharmacol. 650: 233-9. PMID: 20940013
- Delta-opioid receptors mediate unique plasticity onto parvalbumin-expressing interneurons in area CA2 of the hippocampus. | Piskorowski, RA. and Chevaleyre, V. 2013. J Neurosci. 33: 14567-78. PMID: 24005307
- β-Arrestin 2 dependence of Δ opioid receptor agonists is correlated with alcohol intake. | Chiang, T., et al. 2016. Br J Pharmacol. 173: 332-43. PMID: 26507558
- A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. | Levoye, A., et al. 2015. Front Endocrinol (Lausanne). 6: 167. PMID: 26617570
- Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA. | Islam, A., et al. 2020. ACS Pharmacol Transl Sci. 3: 907-920. PMID: 33073190
- Characterization of opioidergic mechanisms related to the anti-migraine effect of vagus nerve stimulation. | Hu, B., et al. 2021. Neuropharmacology. 195: 108375. PMID: 33444636
- Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons. | He, XJ., et al. 2021. Elife. 10: PMID: 34787079
- Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. | Negus, SS., et al. 1998. J Pharmacol Exp Ther. 286: 362-75. PMID: 9655881
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DOR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNC 162, 10 mg | sc-204292 | 10 mg | $1248.00 | |||
SNC 162, 50 mg | sc-204292A | 50 mg | $5826.00 |