SNARK Antibody (H-3): sc-374500
- SNARK Antibody (H-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 559-591 near the C-terminus of SNARK of human origin
- recommended for detection of SNARK of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SNARK Antibody (H-3) for WB applications. These reagents are now offered in bundles with SNARK Antibody (H-3) (see ordering information below).
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SEE ALSO...
SNARK Antibody (H-3) is a mouse monoclonal IgG1 antibody that detects SNARK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNARK, also known as NUAK2, is a 628 amino acid protein that plays a crucial role in cellular signaling by functioning as a serine/threonine protein kinase. SNARK contains a single protein kinase domain and utilizes magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins, which is vital for regulating various cellular processes, including stress response and glucose metabolism. SNARK′s ability to modulate cell tolerance to stress-induced glucose starvation highlights its importance in maintaining cellular homeostasis, particularly under adverse conditions. Furthermore, SNARK is implicated in promoting cell-cell detachment and may offer protection against Fap-1-mediated apoptosis, suggesting potential involvement in the motility and invasiveness of tumor cells. Anti-SNARK antibody (H-3) is an essential tool for researchers investigating the intricate roles of this kinase in cellular dynamics and disease mechanisms.
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SNARK Antibody (H-3) References:
- An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers. | Vallenius, T., et al. 2011. J Cell Sci. 124: 384-93. PMID: 21242312
- AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma. | Namiki, T., et al. 2011. Proc Natl Acad Sci U S A. 108: 6597-602. PMID: 21460252
- Neural tube defects by NUAK1 and NUAK2 double mutation. | Ohmura, T., et al. 2012. Dev Dyn. 241: 1350-64. PMID: 22689267
- The regulation and function of the NUAK family. | Sun, X., et al. 2013. J Mol Endocrinol. 51: R15-22. PMID: 23873311
- Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output. | Kolliopoulos, C., et al. 2019. J Biol Chem. 294: 4119-4136. PMID: 30622137
- lncRNA FGD5‑AS1 promotes breast cancer progression by regulating the hsa‑miR‑195‑5p/NUAK2 axis. | Fang, K., et al. 2021. Mol Med Rep. 23: PMID: 33880593
- NUAK family kinase 2 is a novel therapeutic target for prostate cancer. | Fu, W., et al. 2022. Mol Carcinog. 61: 334-345. PMID: 34818445
- OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession. | Guo, Z. and Guo, L. 2024. Dig Liver Dis. 56: 352-362. PMID: 37429790
- Activated Akt expression is associated with the recurrence of primary melanomas and further refines the prognostic and predictive values for relapse in acral melanomas. | Nojima, K., et al. 2024. Pigment Cell Melanoma Res. 37: 36-44. PMID: 37596787
- A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma. | Jo, H., et al. 2025. bioRxiv.. PMID: 39803558
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNARK Antibody (H-3) | sc-374500 | 200 µg/ml | $322.00 | |||
SNARK Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-540464 | 200 µg Ab; 10 µg BP | $361.00 | |||
SNARK Antibody (H-3): m-IgG1 BP-HRP Bundle | sc-542141 | 200 µg Ab; 20 µg BP | $361.00 | |||
SNARK (H-3) Neutralizing Peptide | sc-374500 P | 100 µg/0.5 ml | $69.00 |