SNAPC 43 Antibody (3025C1a): sc-81571

SNAPC 43 Antibody (3025C1a) is a mouse monoclonal IgG1 antibody that detects SNAPC 43 of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-SNAPC 43 antibody (3025C1a) is available as the non-conjugated format. SNAPC 43 plays a crucial role in the regulation of gene transcription, particularly in the context of small nuclear RNA (snRNA) synthesis. SNAPC 43 serves as a key component of the snRNA-activating protein complex (SNAPC), which is essential for the transcriptional activation of both RNA polymerase II and III. This complex is unique because SNAPC binds to a non-TATA-box proximal sequence element (PSE), allowing for the regulation of basal transcription in a manner distinct from traditional TATA-box binding mechanisms. SNAPC complex is composed of five subunits, with SNAPC 43 (also known as PTFγ) interacting with other subunits such as SNAPC 50, which contains zinc finger motifs that facilitate this interaction. Assembly of these subunits is critical for the formation of a functional transcription regulator, highlighting SNAPC 43′s importance in the transcriptional machinery of the cell. Using SNAPC 43 (3025C1a) monoclonal antibody can provide valuable insights into the mechanisms of gene regulation and the intricate processes that govern RNA synthesis in human cells.

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SNAPC 43 Antibody (3025C1a) References:

1. A positioned nucleosome on the human U6 promoter allows recruitment of SNAPc by the Oct-1 POU domain.  |  Zhao, X., et al. 2001. Mol Cell. 7: 539-49. PMID: 11463379
2. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III.  |  Henry, RW., et al. 1995. Nature. 374: 653-6. PMID: 7715707
3. Targeting TBP to a non-TATA box cis-regulatory element: a TBP-containing complex activates transcription from snRNA promoters through the PSE.  |  Sadowski, CL., et al. 1993. Genes Dev. 7: 1535-48. PMID: 8339931
4. The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein.  |  Sadowski, CL., et al. 1996. Proc Natl Acad Sci U S A. 93: 4289-93. PMID: 8633057
5. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc.  |  Henry, RW., et al. 1996. EMBO J. 15: 7129-36. PMID: 9003788
6. Role for the amino-terminal region of human TBP in U6 snRNA transcription.  |  Mittal, V. and Hernandez, N. 1997. Science. 275: 1136-40. PMID: 9027316
7. Characterization of a trimeric complex containing Oct-1, SNAPc, and DNA.  |  Ford, E. and Hernandez, N. 1997. J Biol Chem. 272: 16048-55. PMID: 9188510
8. SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III.  |  Henry, RW., et al. 1998. Genes Dev. 12: 2664-72. PMID: 9732265
9. The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1.  |  Ford, E., et al. 1998. Genes Dev. 12: 3528-40. PMID: 9832505

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNAPC 43 Antibody (3025C1a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SNAPC 43 Antibody (3025C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNAPC 43 Antibody (3025C1a) Specifications

Alternate Product Name: SNAPC 43

Product Clone Name: 3025C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: SNAPC 43

Epitope Species: human

Product Reactivity/Detection: SNAPC 43

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SNAPC 43 Antibody (3025C1a): N/A