SNAPC 190 Antibody (SNAAD17A): sc-81379

SNAPC 190 Antibody (SNAAD17A) is a mouse monoclonal IgG1 antibody that detects SNAPC 190 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). SNAPC 190 plays a crucial role in the assembly of the snRNA-activating protein complex (SNAPC), which is essential for the regulation of basal transcription by RNA polymerases II and III. SNAPC 190 is located in the nucleus, where SNAPC 190 interacts with other transcription factors, including Oct-1 and TATA-box binding protein (TBP), to facilitate the transcription of small nuclear RNAs. The proper localization of SNAPC 190 within the nucleus is vital for its function, as SNAPC 190 ensures that the transcription machinery is effectively recruited to the non-TATA-box proximal sequence element (PSE) for accurate gene expression. The cooperative binding of SNAPC 190 with Oct-1 is mediated by a nucleosome positioned between their respective binding sites, highlighting the importance of spatial organization in transcription regulation. Anti-SNAPC 190 antibody (SNAAD17A) enables researchers to gain insights into the mechanisms of transcription regulation and the role of SNAPC in cellular processes, making SNAPC 190 (SNAAD17A) antibody an invaluable tool for studies in molecular biology and gene expression.

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SNAPC 190 Antibody (SNAAD17A) References:

1. Crossing the line between RNA polymerases: transcription of human snRNA genes by RNA polymerases II and III.  |  Henry, RW., et al. 1998. Cold Spring Harb Symp Quant Biol. 63: 111-20. PMID: 10384275
2. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc.  |  Ma, B. and Hernandez, N. 2001. J Biol Chem. 276: 5027-35. PMID: 11056176
3. Redundant cooperative interactions for assembly of a human U6 transcription initiation complex.  |  Ma, B. and Hernandez, N. 2002. Mol Cell Biol. 22: 8067-78. PMID: 12391172
4. Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III.  |  Hanzlowsky, A., et al. 2006. Protein Expr Purif. 48: 215-23. PMID: 16603380
5. Architectural arrangement of the small nuclear RNA (snRNA)-activating protein complex 190 subunit (SNAP190) on U1 snRNA gene promoter DNA.  |  Doherty, MT., et al. 2012. J Biol Chem. 287: 39369-79. PMID: 23038247
6. The Myb domain of the largest subunit of SNAPc adopts different architectural configurations on U1 and U6 snRNA gene promoter sequences.  |  Kang, YS., et al. 2014. Nucleic Acids Res. 42: 12440-54. PMID: 25324315
7. The role of plasma exosomal lnc-SNAPC5-3:4 in monitoring the efficacy of anlotinib in the treatment of advanced non-small cell lung cancer.  |  Liu, C., et al. 2022. J Cancer Res Clin Oncol. 148: 2867-2879. PMID: 35672525
8. Long noncoding RNA lnc-SNAPC5-3:4 inhibits malignancy by directly upregulating miR-224-3p in non-small cell lung cancer.  |  Hu, C., et al. 2024. Heliyon. 10: e24668. PMID: 38312596
9. Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters.  |  Shah, SZ., et al. 2025. Nat Commun. 16: 141. PMID: 39747245
10. Brain gliomas new transcriptomic discoveries from differentially expressed genes to therapeutic targets.  |  Pei, S., et al. 2025. Sci Rep. 15: 2553. PMID: 39833228
11. Coiled bodies and U2 snRNA genes adjacent to coiled bodies are enriched in factors required for snRNA transcription.  |  Schul, W., et al. 1998. Mol Biol Cell. 9: 1025-36. PMID: 9571237
12. SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III.  |  Henry, RW., et al. 1998. Genes Dev. 12: 2664-72. PMID: 9732265

The preferred SNAPC 190 antibody is SNAPC 190 Antibody (B-11): sc-515660.