Molecular structure of SNAP 94847 hydrochloride, CAS Number: 487051-12-7
SNAP 94847 hydrochloride (CAS 487051-12-7)
Alternate Names:
N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamide hydrochloride
Application:
SNAP 94847 hydrochloride is a potent MCH-1R (melanin-concentrating hormone receptor 1) antagonist
CAS Number:
487051-12-7
Molecular Weight:
515.03
Molecular Formula:
C29H32F2O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A potent melanin-concentrating hormone receptor 1 (MCH1) antagonist (Ki = 2.2 nM, KD = 530 pM) that displays > 80-fold and > 500-fold selectivity over α1A and D2 receptors respectively. Has been shown to increase neurogenesis in the dentate gyrus and decreases food-reinforced operant responding in vivo. Exhibits anxiolytic activity and is orally active.
SNAP 94847 hydrochloride (CAS 487051-12-7) References
- Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. | David, DJ., et al. 2007. J Pharmacol Exp Ther. 321: 237-48. PMID: 17237257
- Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. | Chen, CA., et al. 2007. J Med Chem. 50: 3883-90. PMID: 17668922
- Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats. | Nair, SG., et al. 2009. Psychopharmacology (Berl). 205: 129-40. PMID: 19340414
- Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays. | Lin, CH., et al. 2016. Eur J Pharm Sci. 89: 11-9. PMID: 27094783
- Natural hypothalamic circuit dynamics underlying object memorization. | Kosse, C. and Burdakov, D. 2019. Nat Commun. 10: 2505. PMID: 31175285
- Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus. | Concetti, C., et al. 2024. J Neurosci. 44: PMID: 38575343
Inhibitor of:
MCH-1R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNAP 94847 hydrochloride, 10 mg | sc-311536 | 10 mg | $199.00 | |||
SNAP 94847 hydrochloride, 50 mg | sc-311536A | 50 mg | $825.00 |