Sn(IV) Mesoporphyrin IX dichloride (CAS 106344-20-1)
See product citations (5)
QUICK LINKS
Sn(IV) Mesoporphyrin IX dichloride is a compound that functions as a potent inhibitor of heme oxygenase. It acts by binding to the active site of heme oxygenase, preventing the conversion of heme to biliverdin, carbon monoxide, and free iron. This inhibition disrupts the normal breakdown of heme, leading to an accumulation of heme and a decrease in the production of biliverdin, carbon monoxide, and free iron. As a result, Sn(IV) Mesoporphyrin IX dichloride effectively modulates the heme oxygenase pathway, impacting cellular processes and signaling pathways that are regulated by heme degradation products. Sn(Iv) Mesoporphyrin Ix Dichloride′s mechanism of action involves interfering with the enzymatic activity of heme oxygenase, ultimately influencing the downstream biological effects associated with heme metabolism.
Sn(IV) Mesoporphyrin IX dichloride (CAS 106344-20-1) References
- Leishmania pifanoi amastigotes avoid macrophage production of superoxide by inducing heme degradation. | Pham, NK., et al. 2005. Infect Immun. 73: 8322-33. PMID: 16299330
- Inhibition of hemoxygenase-1 improves survival after liver resection in jaundiced rats. | Scheingraber, S., et al. 2009. Eur Surg Res. 42: 157-67. PMID: 19176968
- Tumoral immune suppression by macrophages expressing fibroblast activation protein-α and heme oxygenase-1. | Arnold, JN., et al. 2014. Cancer Immunol Res. 2: 121-6. PMID: 24778275
- Erythropoietin Attenuates Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension through Interplay between Endothelial Progenitor Cells and Heme Oxygenase. | van Loon, RL., et al. 2015. Front Pediatr. 3: 71. PMID: 26380246
- Isoliquiritigenin pretreatment attenuates cisplatin induced proximal tubular cells (LLC-PK1) death and enhances the toxicity induced by this drug in bladder cancer T24 cell line. | Patricia Moreno-Londoño, A., et al. 2017. Food Chem Toxicol. 109: 143-154. PMID: 28870684
- Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer. | Muliaditan, T., et al. 2018. Clin Cancer Res. 24: 1617-1628. PMID: 29339440
- Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis. | Muliaditan, T., et al. 2018. Nat Commun. 9: 2951. PMID: 30054470
- Premature Macrophage Activation by Stored Red Blood Cell Transfusion Halts Liver Regeneration Post-Partial Hepatectomy in Rats. | Abudi, N., et al. 2022. Cells. 11: PMID: 36359918
- Detection and Mitigation of IoT-Based Attacks Using SNMP and Moving Target Defense Techniques. | Gayathri, R., et al. 2023. Sensors (Basel). 23: PMID: 36772751
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sn(IV) Mesoporphyrin IX dichloride, 25 mg | sc-264307 | 25 mg | $260.00 | |||
Sn(IV) Mesoporphyrin IX dichloride, 100 mg | sc-264307A | 100 mg | $515.00 | |||
Sn(IV) Mesoporphyrin IX dichloride, 1 g | sc-264307B | 1 g | $4085.00 |