Smuc Antibody (E-3): sc-390438

Smuc Antibody (E-3) is a mouse monoclonal IgM antibody that detects Smuc protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Smuc antibody (E-3) is available as the non-conjugated form. Smuc (E-3) antibody recognizes a member of the Snail family of developmental regulatory proteins, which plays a crucial role in transcriptional regulation and is characterized by five putative DNA-binding zinc finger domains located at the C-terminal region. This structural feature allows Smuc to preferentially bind to specific E-box motifs, such as CAGGTG and CACCTG, thereby influencing gene expression patterns essential for cellular processes. Smuc (E-3) monoclonal antibody targets a protein highly expressed in skeletal muscle and thymus tissues, where Smuc contributes to the repression of gene transcription, a function vital for maintaining tissue identity and function. Smuc′s ability to modulate gene expression is particularly important in muscle development and immune response, highlighting potential implications in various biological processes and diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Smuc Antibody (E-3) References:

1. Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region.  |  Stegmann, K., et al. 1999. Mutat Res. 406: 63-9. PMID: 10479723
2. SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.  |  Inukai, T., et al. 1999. Mol Cell. 4: 343-52. PMID: 10518215
3. Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis.  |  Twigg, SR. and Wilkie, AO. 1999. Hum Genet. 105: 320-6. PMID: 10543399
4. Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P).  |  Paznekas, WA., et al. 1999. Genomics. 62: 42-9. PMID: 10585766
5. A novel snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs.  |  Kataoka, H., et al. 2000. Nucleic Acids Res. 28: 626-33. PMID: 10606664
6. Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene.  |  Nieto, MA., et al. 1992. Development. 116: 227-37. PMID: 1483390
7. Human SLUG gene organization, expression, and chromosome map location on 8q.  |  Cohen, ME., et al. 1998. Genomics. 51: 468-71. PMID: 9721220
8. Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene.  |  Jiang, R., et al. 1998. Biochim Biophys Acta. 1443: 251-4. PMID: 9838149

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Smuc Antibody (E-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Smuc Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Smuc Antibody (E-3) Specifications

Alternate Product Name: Smuc

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 25-63

Epitope Target: Smuc

Epitope Species: mouse

Product Reactivity/Detection: Smuc

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Smuc Antibody (E-3): P: Blocking Peptide, X: TransCruz Reagent