SM-19712 (CAS 194542-56-8)
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SM-19712 is a chemical that functions as a potent and selective inhibitor of a specific enzyme involved in cellular signaling pathways. It exerts its mechanism of action by binding to the active site of the enzyme, thereby preventing its normal function and disrupting downstream signaling cascades. This disruption ultimately leads to the modulation of various cellular processes, including gene expression, cell proliferation, and apoptosis. By targeting this specific enzyme, SM-19712 has the ability to influence the behavior and fate of cells in experimental applications. Its precise mechanism of action at the molecular level may be investigating the role of the targeted enzyme in various cellular processes. Its selectivity for the enzyme of interest allows for the specific manipulation of signaling pathways, providing insights into their functional significance in cellular physiology.
SM-19712 (CAS 194542-56-8) References
- Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme. | Umekawa, K., et al. 2000. Jpn J Pharmacol. 84: 7-15. PMID: 11043447
- Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats. | Matsumura, Y., et al. 2000. Jpn J Pharmacol. 84: 16-24. PMID: 11043448
- The endothelin system and its role in acute myocardial infarction. | Doggrell, SA. 2004. Expert Opin Ther Targets. 8: 191-201. PMID: 15161426
- Endothelin-converting enzyme-1 degrades internalized somatostatin-14. | Roosterman, D., et al. 2008. Endocrinology. 149: 2200-7. PMID: 18276747
- Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. | Tawa, M., et al. 2008. Eur J Pharmacol. 591: 182-8. PMID: 18586023
- Fibrinogen-induced endothelin-1 production from endothelial cells. | Sen, U., et al. 2009. Am J Physiol Cell Physiol. 296: C840-7. PMID: 19193866
- Effects of the endothelin-converting enzyme inhibitor SM-19712 in a mouse model of dextran sodium sulfate-induced colitis. | Lee, S., et al. 2009. Inflamm Bowel Dis. 15: 1007-13. PMID: 19202571
- Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation. | Cattaruzza, F., et al. 2009. Br J Pharmacol. 156: 730-9. PMID: 19222484
- Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries. | Goel, A., et al. 2010. Circ Res. 107: 242-51. PMID: 20522806
- Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts. | Tawa, M., et al. 2011. Hypertens Res. 34: 218-24. PMID: 21048781
- Contribution of nitric oxide in big endothelin-1-induced cardioprotective effects on ischemia/reperfusion injury in rat hearts. | Tawa, M., et al. 2011. J Cardiovasc Pharmacol. 57: 575-8. PMID: 21326108
- Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones. | Pelayo, JC., et al. 2011. J Physiol. 589: 5213-30. PMID: 21878523
- Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries. | McNeish, AJ., et al. 2012. Br J Pharmacol. 167: 1679-90. PMID: 22881710
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SM-19712, 5 mg | sc-215859 | 5 mg | $235.00 | |||
SM-19712, 25 mg | sc-215859A | 25 mg | $869.00 |