SLMAP Antibody (D-3): sc-393393
- SLMAP Antibody (D-3) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 606-828 mapping at the C-terminus of SLMAP of human origin
- recommended for detection of SLMAP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SLMAP Antibody (D-3) for WB and IHC(P) applications. These reagents are now offered in bundles with SLMAP Antibody (D-3) (see ordering information below).
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SLMAP Antibody (D-3) is a mouse monoclonal IgG2a antibody that detects SLMAP (sarcolemmal membrane-associated protein) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SLMAP is a crucial 828 amino acid single-pass type IV membrane protein primarily localized to the sarcolemma in non-replicating cells, where SLMAP plays a significant role in muscle tissue dynamics. During cellular cleavage, SLMAP relocates to centrosomes in a microtubule-dependent manner, highlighting SLMAP′s importance in cellular organization and function. SLMAP facilitates protein-protein interactions and is integral to myoblast fusion, which is essential for muscle development and repair. Structurally, SLMAP exists as a homodimeric integral membrane protein featuring two leucine zippers that form a 77 amino acid coiled-coil structure, along with a forkhead-associated (FHA) domain. The coiled-coil structure is particularly important for regulating neurotransmitter release, N-type calcium channels, and membrane fusion, while the FHA domain is involved in nuclear signaling pathways. SLMAP is produced in eight isoforms through alternative splicing, allowing for diverse functional roles in various cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
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SLMAP Antibody (D-3) References:
- Progressive loss of myogenic differentiation in leiomyosarcoma has prognostic value. | Demicco, EG., et al. 2015. Histopathology. 66: 627-38. PMID: 24889065
- Genetic interpretation and clinical translation of minor genes related to Brugada syndrome. | Campuzano, O., et al. 2019. Hum Mutat. 40: 749-764. PMID: 30821013
- SLMAP3 isoform modulates cardiac gene expression and function. | Mlynarova, J., et al. 2019. PLoS One. 14: e0214669. PMID: 30934005
- Colorectal Adenocarcinomas Harboring ALK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 12 Cases and Review of the Literature. | Lasota, J., et al. 2020. Am J Surg Pathol. 44: 1224-1234. PMID: 32804454
- Pan-Cancer Analysis on the Oncogenic Role of Programmed Cell Death 10. | Sun, N., et al. 2022. J Oncol. 2022: 1242658. PMID: 36276268
- DNA Methylation Alterations in Fractionally Irradiated Rats and Breast Cancer Patients Receiving Radiotherapy. | Sallam, M., et al. 2022. Int J Mol Sci. 23: PMID: 36555856
- Striatins and STRIPAK complex partners in clinical outcomes of patients with breast cancer and responses to drug treatment. | Li, AX., et al. 2023. Chin J Cancer Res. 35: 365-385. PMID: 37691891
- Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation. | Gadre, A., et al. 2024. JID Innov. 4: 100263. PMID: 38585195
- SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. | Rehmani, T., et al. 2024. Life Sci Alliance. 7: PMID: 39366759
- SLMAP3 is crucial for organogenesis through mechanisms involving primary cilia formation. | Dias, AP., et al. 2024. Open Biol. 14: rsob240206. PMID: 39417621
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SLMAP Antibody (D-3) | sc-393393 | 200 µg/ml | $322.00 | |||
SLMAP Antibody (D-3): m-IgG Fc BP-HRP Bundle | sc-538204 | 200 µg Ab; 10 µg BP | $361.00 | |||
SLMAP Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-535772 | 200 µg Ab; 40 µg BP | $361.00 | |||
SLMAP Antibody (D-3): m-IgG2a BP-HRP Bundle | sc-548231 | 200 µg Ab; 10 µg BP | $361.00 |