SLM-1 Antibody (7G8C10): sc-517231

SLM-1 Antibody (7G8C10) is a mouse monoclonal IgG1 antibody that detects SLM-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-SLM-1 antibody (7G8C10) is available as non-conjugated format. SLM-1 plays a crucial role in cellular signaling through regulation of RNA binding and acts as an adapter protein for various signaling molecules, including GRB2, PLC γ1, Fyn, and RasGAP. This interaction is vital for signal transduction that influences cell growth, differentiation, and response to external stimuli. Notably, SLM-1 phosphorylation on tyrosine residues enhances interaction with these signaling proteins, thereby modulating downstream pathways. SLM-1′s RNA binding capability suggests involvement in post-transcriptional regulation, making SLM-1 an important player in gene expression control. Furthermore, while SLM-1 shares functional similarities with homologs SLM-2 and Sam 68, SLM-1 exhibits distinct properties, such as specific phosphorylation status and interaction profile, which underscores a unique role in cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SLM-1 Antibody (7G8C10) References:

1. Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.  |  Di Fruscio, M., et al. 1999. Proc Natl Acad Sci U S A. 96: 2710-5. PMID: 10077576
2. A target for Src in mitosis.  |  Fumagalli, S., et al. 1994. Nature. 368: 871-4. PMID: 7512695
3. A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma.  |  Maa, MC., et al. 1994. Mol Cell Biol. 14: 5466-73. PMID: 7518563
4. Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.  |  Richard, S., et al. 1995. Mol Cell Biol. 15: 186-97. PMID: 7799925
5. The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein.  |  Lock, P., et al. 1996. Cell. 84: 23-4. PMID: 8548822
6. Sam68 is a Ras-GAP-associated protein in mitosis.  |  Guitard, E., et al. 1998. Biochem Biophys Res Commun. 245: 562-6. PMID: 9571195

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLM-1 Antibody (7G8C10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SLM-1 Antibody (7G8C10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLM-1 Antibody (7G8C10) Specifications

Alternate Product Name: SLM-1

Product Clone Name: 7G8C10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 160-349

Epitope Target: SLM-1

Epitope Species: human

Product Reactivity/Detection: SLM-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SLM-1 Antibody (7G8C10): N/A