SLC2A4RG Antibody (K-41): sc-130464

SLC2A4RG Antibody (K-41) is a mouse monoclonal IgG2a kappa light chain antibody that detects SLC2A4RG protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-SLC2A4RG antibody (K-41) is available as a non-conjugated format. SLC2A4RG protein, also known as SLC2A4 regulator, Huntington disease gene regulatory region-binding protein 1, and GLUT4 enhancer factor, is a crucial transcription factor composed of 387 amino acids that plays a significant role in transactivation of Glut4 and Huntington′s disease (HD) genes. SLC2A4RG regulates Glut4 transcription by binding to domain I of Glut4 promoter in collaboration with MEF-2, and SLC2A4RG activity increases following exercise, which enhances DNA binding activities of both SLC2A4RG and MEF-2, leading to elevated Glut4 transcription. Glut4 overexpression in skeletal muscle improves glucose homeostasis and enhances insulin sensitivity, making SLC2A4RG essential for metabolic health. SLC2A4RG recognizes 5′-GCCGGCG-3′ DNA sequence motif within HD promoter, influencing HD gene transcription. SLC2A4RG shows ubiquitous expression, with highest levels in skeletal muscle, liver, kidney, heart, and pancreas, shuttling between cytoplasm and nucleus with a C2H2-type zinc finger essential for DNA binding capabilities. Two SLC2A4RG isoforms arise from alternative splicing, diversifying functional roles in cellular processes.

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SLC2A4RG Antibody (K-41) References:

1. Identification of a 30-base pair regulatory element and novel DNA binding protein that regulates the human GLUT4 promoter in transgenic mice.  |  Oshel, KM., et al. 2000. J Biol Chem. 275: 23666-73. PMID: 10825161
2. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene.  |  Tanaka, K., et al. 2004. J Biol Chem. 279: 7275-86. PMID: 14625278
3. Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A.  |  Knight, JB., et al. 2003. Proc Natl Acad Sci U S A. 100: 14725-30. PMID: 14630949
4. Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase.  |  Holmes, BF., et al. 2005. Am J Physiol Endocrinol Metab. 289: E1071-6. PMID: 16105857
5. Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle.  |  McGee, SL., et al. 2006. FASEB J. 20: 348-9. PMID: 16368714
6. GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes.  |  Sparling, DP., et al. 2008. J Biol Chem. 283: 7429-37. PMID: 18216015
7. Myocyte enhancer factor 2 (MEF2)-binding site is required for GLUT4 gene expression in transgenic mice. Regulation of MEF2 DNA binding activity in insulin-deficient diabetes.  |  Thai, MV., et al. 1998. J Biol Chem. 273: 14285-92. PMID: 9603935

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLC2A4RG Antibody (K-41) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SLC2A4RG Antibody (K-41) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLC2A4RG Antibody (K-41) Specifications

Alternate Product Name: SLC2A4RG

Product Clone Name: K-41

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 178-270

Epitope Target: SLC2A4RG

Epitope Species: human

Product Reactivity/Detection: SLC2A4RG

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SLC2A4RG Antibody (K-41): N/A