SLC25A25 Antibody (4D8): sc-517143
- SLC25A25 Antibody (4D8) is a mouse monoclonal IgG2a κ SLC25A25 antibody provided at 100 µg/ml
- raised against amino acids 2-110 representing partial length SLC25A25 of human origin
- recommended for detection of SLC25A25 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SLC25A25 Antibody (4D8). This work is in progress.
SLC25A25 Antibody (4D8) is a mouse monoclonal IgG2a kappa light chain antibody that detects SLC25A25 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SLC25A25 antibody (4D8) is available as a non-conjugated antibody. SLC25A25 protein, also known as MCSC (mitochondrial calcium-dependent solute carrier protein), PCSCL, or SCaMC-2 (small calcium-binding mitochondrial carrier protein 2), is a crucial 469 amino acid multi-pass membrane protein that plays a significant role in mitochondrial function. SLC25A25 is part of the solute carrier family 25, which is responsible for the transport of metabolites across the inner mitochondrial membrane. SLC25A25 is primarily localized to the inner mitochondrial membrane and is essential for cellular energy metabolism, as SLC25A25 functions as a calcium-dependent mitochondrial solute carrier. Specifically, SLC25A25 facilitates the transport of magnesium-bound ATP in exchange for phosphate, a process vital for maintaining ATP levels and cellular energy homeostasis. SLC25A25′s structure includes three Solcar repeats and three EF-hand domains, which are critical for calcium-binding capability and transport function. Alternative splicing of the SLC25A25 gene results in six isoforms, with SCaMC-2a being ubiquitously expressed, while SCaMC-2b is predominantly found in lung and kidney tissues. SLC25A25′s ability to regulate mitochondrial calcium levels and ATP transport underscores SLC25A25′s importance in various physiological processes, including muscle contraction and neuronal signaling, making SLC25A25 a valuable target for research in cellular metabolism and related disorders.
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SLC25A25 Antibody (4D8) References:
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. | Nagase, T., et al. 2001. DNA Res. 8: 179-87. PMID: 11572484
- A novel mitochondrial Ca2+-dependent solute carrier in the liver identified by mRNA differential display. | Mashima, H., et al. 2003. J Biol Chem. 278: 9520-7. PMID: 12645546
- Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. | del Arco, A. and Satrústegui, J. 2004. J Biol Chem. 279: 24701-13. PMID: 15054102
- Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution. | Fiermonte, G., et al. 2004. J Biol Chem. 279: 30722-30. PMID: 15123600
- Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family. | Bassi, MT., et al. 2005. Gene. 345: 173-82. PMID: 15716113
- Novel variants of human SCaMC-3, an isoform of the ATP-Mg/P(i) mitochondrial carrier, generated by alternative splicing from 3'-flanking transposable elements. | Del Arco, A. 2005. Biochem J. 389: 647-55. PMID: 15801905
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SLC25A25 Antibody (4D8) | sc-517143 | 100 µg/ml | $316.00 |