Molecular structure of SL-327, CAS Number: 305350-87-2
SL-327 (CAS 305350-87-2)
See product citations (7)
Alternate Names:
Mek-1/Mek-2 Inhibitor
Application:
SL-327 is a selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations
CAS Number:
305350-87-2
Purity:
≥98%
Molecular Weight:
335.35
Molecular Formula:
C16H12F3N3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SL-327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively). This compound may act to block hippocampal LTP via inhibition of the MAPK/ERK cascade, which prevents CREB and Elk-1 phosphorylation, and LTP-dependent gene induction, resulting in rapidly decaying LTP, while being uncompetitive with respect to ATP. SL-327 has also been shown to inhibit ERK1, MEK-3/p38, MEK-4, JNK, and PKC activities when used at higher concentrations.
SL-327 (CAS 305350-87-2) References
- The MAPK cascade is required for mammalian associative learning. | Atkins, CM., et al. 1998. Nat Neurosci. 1: 602-9. PMID: 10196568
- The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. | Davis, S., et al. 2000. J Neurosci. 20: 4563-72. PMID: 10844026
- Coactivation of beta-adrenergic and cholinergic receptors enhances the induction of long-term potentiation and synergistically activates mitogen-activated protein kinase in the hippocampal CA1 region. | Watabe, AM., et al. 2000. J Neurosci. 20: 5924-31. PMID: 10934239
- Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. | Scherle, PA., et al. 2000. J Biol Chem. 275: 37086-92. PMID: 10969080
- Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. | Valjent, E., et al. 2000. J Neurosci. 20: 8701-9. PMID: 11102476
- Differential regulation of IL-1beta and TNF-alpha RNA expression by MEK1 inhibitor after focal cerebral ischemia in mice. | Wang, H., et al. 2001. Biochem Biophys Res Commun. 286: 869-74. PMID: 11527379
- Inducible, pharmacogenetic approaches to the study of learning and memory. | Ohno, M., et al. 2001. Nat Neurosci. 4: 1238-43. PMID: 11713472
- ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. | Hetman, M., et al. 2002. J Biol Chem. 277: 49577-84. PMID: 12393899
- Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. | Wang, X., et al. 2003. J Pharmacol Exp Ther. 304: 172-8. PMID: 12490588
- Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice. | Salzmann, J., et al. 2003. Br J Pharmacol. 140: 831-8. PMID: 14517176
- Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat. | Carr, KD., et al. 2009. Psychopharmacology (Berl). 201: 495-506. PMID: 18766328
- The role of verapamil and SL-327 in morphine- and ethanol-induced state-dependent and cross state-dependent memory. | Michalak, A., et al. 2018. Eur J Pharmacol. 834: 318-326. PMID: 30059684
- Cardiac Protective Role of Heat Shock Protein 27 in the Stress Induced by Drugs of Abuse. | Martínez-Laorden, E., et al. 2020. Int J Mol Sci. 21: PMID: 32455528
- Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice - Possible hippocampal MAPKs specificity. | Michalak, A., et al. 2020. Neuropharmacology. 180: 108302. PMID: 32931814
- α-[Amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile; Configurational equilibria in solution. | McElhinny, CJ., et al. 2021. Bioorg Chem. 113: 104955. PMID: 34034134
Inhibitor of:
0610038D11Rik, 1190003J15Rik, 1500012F01Rik, 1500016O10Rik, 1500035H01Rik, 1700011A15Rik, 1700011F14Rik, 1700011I03Rik, 4930570C03Rik, 4932432K03Rik, 6430706D22Rik, 6530418L21Rik, 8430426H19Rik, 9130017N09Rik, 9130404D08Rik, AHNAK, ALG-3, ANUBL1, ASB-18, AWP1, BC049807, BC051070, C-TAK1, C-TAK1L, C11orf35, C11orf46, C12orf29, C14orf182, C14orf37_3632451O06Rik, C1orf112, C1rb, C2orf61, C5orf28, C630004H02Rik, C6orf162, C6orf165, CCDC142, CCDC28B, cortexin 3, D130059P03Rik, D2Bwg1335e, D4Ertd196e, DBT, Deaf1, DPCD, Ear11, EF-CAB3, EG245297, Enigma, FAM195B, FAM23A, FAM59A, FOXD4L5, FSD1L, GLT1D1, Gm711, GRRP1, GSBS, HIVEP1, Homer-2, IQCF1, KIAA0748_5830405N20Rik, KIAA1797, KIDINS220, LHPP, LIN-1, LOC100041343, LOC654106, LRRC4, MAPBPIP, MAPK15, MAPKBP-1, MDFI, MEK-1, MEK-2, MEK-5, Meteorin, Mkk1, MRI1, MTAC2D1, N4BP1, neuroguidin, NumbL, Oit1, PED7A1, PGs5, PHLDB3, Porimin, PRNPIP, PRRT1B, Rap 2A, RasGRP3, RFX3, Rga1, robo2, RP11-307F22.3, SAMD13, SBK2, SCGF, SDCCAG3, SFT2D2, SH3BGRL3, SH3BP5L, SNED1, SPRED3, Sprouty 3, Ste5, Ste7, T2BP, TAO2, TBC1D8B, TBZF, TEX14, TMEM127, TMEM132D, TRIM46, V1RE10, Vgl-2, ZBTB22, ZFP100, ZFP442, ZFP52, Zfp599, Zfp867, ZFP96, ZNF192, ZNF214, ZNF547, ZNF548, ZNF558, and ZNF566.Activator of:
3pK, DCC, FGF-8F, FRYL, phospholamban, RRP8, and Sox-12.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SL-327, 1 mg | sc-200685 | 1 mg | $107.00 | |||
SL-327, 10 mg | sc-200685A | 10 mg | $332.00 |