Molecular structure of SL 0101-1, CAS Number: 77307-50-7
SL 0101-1 (CAS 77307-50-7)
See product citations (3)
Application:
SL 0101-1 is a selective p90 ribosomal S6 kinase (Rsk) inhibitor
CAS Number:
77307-50-7
Molecular Weight:
516.46
Molecular Formula:
C25H24O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SL 0101-1 is a selective inhibitor of p90 Rsk (ribosomal S6 kinase) (IC50 = 89 nM for Rsk-2). This product does not inhibit upstream kinases such as MEK, Raf and PKC. SL 0101-1 inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line. SL 0101-1 is an artificially created peptide consisting of amino acids that exhibits remarkable efficacy in regulating the inflammatory response. Extensive research has focused on its potential to mitigate inflammation and alleviate oxidative stress.
SL 0101-1 (CAS 77307-50-7) References
- Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function. | Tamanini, A., et al. 2011. Am J Physiol Lung Cell Mol Physiol. 300: L380-90. PMID: 21148790
- Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism. | Frampton, G., et al. 2012. Gut. 61: 268-77. PMID: 22068162
- Inhibition of carbonic anhydrase prevents the Na(+)/H(+) exchanger 1-dependent slow force response to rat myocardial stretch. | Vargas, LA., et al. 2013. Am J Physiol Heart Circ Physiol. 305: H228-37. PMID: 23709596
- RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789. | Nadratowska-Wesolowska, B., et al. 2014. Oncogene. 33: 4823-36. PMID: 24141780
- Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists. | Karaki, S., et al. 2014. Mol Cell Proteomics. 13: 1273-85. PMID: 24637012
- The Neuropeptide Galanin Is Up-Regulated during Cholestasis and Contributes to Cholangiocyte Proliferation. | McMillin, M., et al. 2017. Am J Pathol. 187: 819-830. PMID: 28196718
- Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis. | Park, YH., et al. 2020. Nat Immunol. 21: 857-867. PMID: 32601469
- Metabolic subtype reveals potential therapeutic vulnerability in acute promyelocytic leukaemia. | Sung, JY., et al. 2022. Clin Transl Med. 12: e964. PMID: 35808815
Inhibitor of:
βPAK, ABTB2, AI314976, C10orf111, CCDC64B, CREBL2, DSC54, DSCP1, FAM32A, KIAA0701, NET-6, PAK6, Reptin 52, RES4-22, RFX7, RIFF, Rsk, Rsk-1, Rsk-2, Rsk-3, Rsk-4, Rsk3, TNRC6C, ZNF578, ZNF749, ZNF761, and ZNF765.Activator of:
ARP-1, Cypt2, DOCK 180, FAM92A1, and Rsk-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SL 0101-1, 1 mg | sc-204287 | 1 mg | $200.00 | |||
SL 0101-1, 10 mg | sc-204287A | 10 mg | $353.00 | |||
SL 0101-1, 25 mg | sc-204287B | 25 mg | $772.00 | |||
SL 0101-1, 50 mg | sc-204287C | 50 mg | $1230.00 | |||
SL 0101-1, 100 mg | sc-204287D | 100 mg | $2070.00 |