Molecular structure of SK&F 96365, CAS Number: 130495-35-1
SK&F 96365 (CAS 130495-35-1)
See product citations (2)
Alternate Names:
1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride; SKF-96365 hydrochloride
Application:
SK&F 96365 is a calcium channel protein and Stim 1 inhibitor
CAS Number:
130495-35-1
Purity:
≥98%
Molecular Weight:
402.91
Molecular Formula:
C22H26N2O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SK&F 96365, also known as SKF 96365 is a selective, novel calcium channel protein inhibitor. In stimulated endothelial cells, neutrophils, and platelets, it inhibits receptor-mediated calcium entry at concentrations that do not affect the internal release of Ca2+. SK&F 9636 has also been found to inhibit voltage-gated Ca2+ entry in excitable cells. Additionally, it has been discovered to inhibit TRPC3 and TRPC6 activation and acts as an inhibitor of Stim 1.
SK&F 96365 (CAS 130495-35-1) References
- Receptor-operated Ca2+ entry mediated by TRPC3/TRPC6 proteins in rat prostate smooth muscle (PS1) cell line. | Thebault, S., et al. 2005. J Cell Physiol. 204: 320-8. PMID: 15672411
- Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase. | Blayney, LM., et al. 1991. Biochem J. 273 (Pt 3): 803-6. PMID: 1705117
- SK&F 96365, a receptor-mediated calcium entry inhibitor, inhibits calcium responses to endothelin-1 in NG108-15 cells. | Chan, J. and Greenberg, DA. 1991. Biochem Biophys Res Commun. 177: 1141-6. PMID: 2059205
- Receptor-mediated calcium influx in PC12 cells. ATP and bradykinin activate two independent pathways. | Fasolato, C., et al. 1990. J Biol Chem. 265: 20351-5. PMID: 2122973
- The anti-inflammatory effect of the SOCC blocker SK&F 96365 on mouse lymphocytes after stimulation by Con A or PMA/ionomycin. | Ye, Y., et al. 2011. Immunobiology. 216: 1044-53. PMID: 21470712
- SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. | Merritt, JE., et al. 1990. Biochem J. 271: 515-22. PMID: 2173565
- SK&F 96365 induces apoptosis and autophagy by inhibiting Akt-mTOR signaling in A7r5 cells. | Park, EJ., et al. 2011. Biochim Biophys Acta. 1813: 2157-64. PMID: 21767581
- Calcium influx blocked by SK&F 96365 modulates the LPS plus IFN-γ-induced inflammatory response in murine peritoneal macrophages. | Ye, Y., et al. 2012. Int Immunopharmacol. 12: 384-93. PMID: 22212354
- Multiple effects of SK&F 96365 on ionic currents and intracellular calcium in human endothelial cells. | Schwarz, G., et al. 1994. Cell Calcium. 15: 45-54. PMID: 7511989
- Inhibition by SK&F 96365 of Ca2+ current, IL-2 production and activation in T lymphocytes. | Chung, SC., et al. 1994. Br J Pharmacol. 113: 861-8. PMID: 7858878
- Dual effects of SK&F 96365 in human leukemic HL-60 cells. Inhibition of calcium entry and activation of a novel cation influx pathway. | Leung, YM., et al. 1996. Biochem Pharmacol. 51: 605-12. PMID: 8615896
- Capacitative Ca2+ entry in HL-60 cells: tetrandrine and SK & F 96365 as probes. | Leung, YM., et al. 1996. Zhongguo Yao Li Xue Bao. 17: 97-101. PMID: 9772652
- SK&F 96365 (1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenylethyl]-1H- imidazole hydrochloride) stimulates phosphoinositide hydrolysis in human U373 MG astrocytoma cells. | Arias-Montaño, JA., et al. 1998. Biochem Pharmacol. 56: 1023-7. PMID: 9776313
Inhibitor of:
2610021K21Rik, 4930408G06Rik, 4931407G18Rik, 5730419I09Rik, 6330403A02Rik, AHCYL2, ANKTM1, AQP7, BSPII, C10orf63, C18orf30, C18orf58, C2CD4D, C6orf105, C8β, CAB39L, CaBP1, CaBP8, Calcium Channel Protein, CALHM1, CALHM2, CALR3, calsequestrin 1, CatSperβ, CCDC90A, CHERP, connexin 33, copine 6, CRISP-4, CUTA, DANGER, Eapa2, EFR3B, EG631584, EG666504, EG667485, Gm5849, Grancalcin, HCN1, hippocalcin, HRC, Integrin, IP3KA, IP3KC, IP3R-III, ITPRIPL1, ITPRIPL2, Junctional SR Marker, Junctophilin-4, LTRPC7, MCTP1, MCTP2, Mitsugumin23, MrgA8, MrgA9, mucolipin 1, mucolipin 3, neurocalcin δ, NIPA1, NIPA2, Nir1, Olfr1046, Olfr1090, Olfr110, Olfr1166, Olfr370, Olfr380, Olfr438, Olfr446, Olfr447, Olfr536, Olfr544, Olfr551, Olfr649, Olfr722, Olfr723, Olfr724, Olfr725, Olfr726, Olfr727, Olfr728, Olfr73, Olfr730, Olfr731, Olfr76, Olfr761, Olfr763, Olfr870, Olfr9, Olfr90, Olr1014, OR2T34, OR2W3, Orai2, Orai3, OTRPC4, PAP-2b, parvalbumin α, PIRT, PMCA2, PMCA3, PMR1, Polycystin-1L3, Polycystin-2, SLC41A1, SLC41A3, SNT-2, SPCA1, Stim1, Stim2, Stomatin, STOML3, Synaptotagmin XVII, syncytin, TMCO1, TMCO5, TMEM110, TMEM120B, TMEM150C, TMEM165, TMEM17, TMEM184B, TMEM203, TMEM38A, TMEM63A, TMEM63C, TMEM66, TMEM80, TMEM86B, TMTC2, TMTC3, TPCN2, TRAPPC8, Triadin, Trk1, TRP14, Trp3, Trp4, Trp5, Trp6, Trp7, TRPC3, TRPC4AP, TRPM8, TRPV5, TRPV6, UNC-80, V1RG4, V1RG5, V1RG6, V1RH2, V1RH4, VCAC3, VILIP-2, VILIP-3, Vmn1r159, Vmn1r224, Vmn1r31, Vmn2r13, and Vmn2r14.Activator of:
4931407G18Rik, BC060267, C2CD4D, CaBP2, CaBP5, CaMKIIN2, CANT1, CAPS1, CaT1, CatSperδ, CIB2, CLRN2, EF-CAB7, EF-CAB8, EF-HB, ELKS, Enkurin, FBXW2, GPR108, IPMK, ITPK1, KCNMB3, KIAA0494, KLK12, KRTAP12-1, KRTAP12-2, LOC85449, MAGE-B4, MBLAC1, MS4A4C, N-type Ca++ CP α1B, neurexin I, neuroligin 2, nucleobindin, Orai1, Otg1, OTRPC4, R-Spondin3, SPCA2, Tescalcin, TMEM38B, TPCN1, TRPC5, and X123.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SK&F 96365, 5 mg | sc-201475 | 5 mg | $101.00 | |||
SK&F 96365, 10 mg | sc-201475B | 10 mg | $155.00 | |||
SK&F 96365, 25 mg | sc-201475A | 25 mg | $389.00 | |||
SK&F 96365, 50 mg | sc-201475C | 50 mg | $643.00 |