Date published: 2026-4-12

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SKF 83566 hydrobromide (CAS 108179-91-5)

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Application:
SKF 83566 hydrobromide is a selective and potent D1-like dopamine receptor antagonist
CAS Number:
108179-91-5
Molecular Weight:
413.15
Molecular Formula:
C17H18BrNO•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SKF 83566 hydrobromide is a compound of interest in neurobiology and pharmacology research due to its action as a selective antagonist for the D1 dopamine receptor. It is utilized in studies that explore the dopaminergic signaling pathways and their role in modulating neurological functions and behaviors. By inhibiting the D1 receptors, SKF 83566 hydrobromide helps researchers elucidate the physiological and biochemical processes influenced by this specific receptor subtype, including motor control, cognitive functions, and reward mechanisms. In addition, this compound is applied in the examination of the D1 receptor′s involvement in neurological disorders. It also serves as a tool in receptor binding assays, which are instrumental in determining the affinity and selectivity of ligands for the dopamine receptors.


SKF 83566 hydrobromide (CAS 108179-91-5) References

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  2. D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality.  |  Coppa-Hopman, R., et al. 2009. J Psychopharmacol. 23: 672-85. PMID: 18635697
  3. Amoxapine inhibits delayed outward rectifier K(+) currents in cerebellar granule cells via dopamine receptor and protein kinase A activation.  |  Yang, G., et al. 2011. Cell Physiol Biochem. 28: 163-74. PMID: 21865859
  4. Full-gestational exposure to nicotine and ethanol augments nicotine self-administration by altering ventral tegmental dopaminergic function due to NMDA receptors in adolescent rats.  |  Roguski, EE., et al. 2014. J Neurochem. 128: 701-12. PMID: 24147868
  5. Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood.  |  Sherrill, LK. and Gulley, JM. 2018. Brain Res. 1694: 111-120. PMID: 29792867
  6. Cell-type-specific asynchronous modulation of PKA by dopamine in learning.  |  Lee, SJ., et al. 2021. Nature. 590: 451-456. PMID: 33361810
  7. Analgesia and pain: Dual effect of dopamine on the peripheral nociceptive system is dependent on D2-or D1-like receptor activation.  |  Queiroz, BFG., et al. 2022. Eur J Pharmacol. 922: 174872. PMID: 35300994
  8. Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells.  |  Canton-Josh, JE., et al. 2022. Elife. 11: PMID: 35476632
  9. Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.  |  Burke, DA. and Alvarez, VA. 2022. Cell Rep. 39: 110795. PMID: 35545050
  10. SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors.  |  Ohlstein, EH. and Berkowitz, BA. 1985. Eur J Pharmacol. 108: 205-8. PMID: 3884345
  11. Effects of dopamine D1 antagonists SCH23390 and SK&F83566 on locomotor activities in rats.  |  Meyer, ME., et al. 1993. Pharmacol Biochem Behav. 44: 429-32. PMID: 8446676
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SKF 83566 hydrobromide, 10 mg

sc-361360
10 mg
$132.00

SKF 83566 hydrobromide, 50 mg

sc-361360A
50 mg
$400.00