SK-OV-3 Whole Cell Lysate: sc-364229

SK-OV-3 Whole Cell Lysate is derived from SK-OV-3 cells, a human ovarian adenocarcinoma cell line originally established from the ascites of a 64-year-old Caucasian female with ovarian cancer. This lysate is extensively used in cancer research to explore the molecular mechanisms underlying ovarian cancer progression and metastasis. SK-OV-3 cells are known for their high metastatic potential and resistance to certain chemotherapeutic agents, making the lysate valuable for studying oncogenic signaling pathways and drug resistance mechanisms. Researchers utilize SK-OV-3 Whole Cell Lysate to analyze the expression, phosphorylation, and interactions of key proteins involved in pathways such as PI3K/AKT, MAPK/ERK, and Wnt/β-catenin using techniques like western blotting, immunoprecipitation, and mass spectrometry. This lysate is particularly useful for examining the molecular basis of epithelial-mesenchymal transition (EMT), cell proliferation, and apoptosis. Additionally, SK-OV-3 Whole Cell Lysate aids in investigating the effects of various chemical compounds on these signaling pathways, providing insights into the modulation of cellular processes that drive ovarian cancer progression. By comparing SK-OV-3 lysates with those from normal ovarian epithelial cells, scientists can identify specific molecular alterations associated with ovarian carcinoma, advancing research in cancer biology and uncovering potential molecular targets for further exploration in oncology.