SK-MEL-28 + IFN-α Cell Lysate: sc-2290
- 500 µg protein in 200 µl SDS-PAGE Western blotting buffer
- human whole cell lysate; malignant melanoma cells induced with IFN-α
- whole cell lysate provided as Western blotting positive control
- should be stored at -20°C and repeated freezing and thawing should be minimized
- sample vial should be placed at 95° C for up to 5 minutes, once prior to use
QUICK LINKS
SEE ALSO...
SK-MEL-28 + IFN-α cell lysate comes from the SK-MEL-28 human melanoma cell line treated with interferon-alpha (IFN-α), a cytokine extensively studied for its role in antiviral responses and immune modulation. This lysate is a critical tool for researching the effects of IFN-α on melanoma cells, focusing on how it influences antiproliferative and apoptotic pathways. IFN-α treatment in SK-MEL-28 cells typically leads to the activation of the JAK-STAT signaling pathway, crucial for transmitting the antiviral and antitumoral effects of IFN-α into the cell nucleus. Researchers utilize this lysate to study the transcriptional activation of genes involved in antiproliferative responses and to analyze changes in protein expression related to cell cycle regulation. The lysate is also used to examine the modulation of tumor antigens and the upregulation of adhesion molecules, which are essential for understanding how melanoma cells interact with components of the immune system. By investigating these mechanisms, the SK-MEL-28 + IFN-α cell lysate provides insights into the cellular dynamics under cytokine influence, offering valuable data on the basic biological responses to IFN-α.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SK-MEL-28 + IFN-α Cell Lysate | sc-2290 | 500 µg/200 µl | $118.00 |