SK-LMS-1 Cell Lysate: sc-3813

SK-LMS-1 cell lysate is derived from a human leiomyosarcoma cell line, serving as a crucial tool in cancer biology research focused specifically on smooth muscle tumors. This lysate facilitates the investigation of unique cellular pathways and protein interactions relevant to leiomyosarcoma. Researchers utilize SK-LMS-1 to examine the role of specific oncogenes and tumor suppressor genes in sarcoma pathogenesis. It is instrumental in studying altered signaling pathways, such as the TGF-beta pathway, which is often implicated in the differentiation and proliferation of sarcomatous cells. Additionally, the lysate aids in exploring mechanisms of resistance to apoptosis, a common trait in cancer cells, by analyzing the expression levels and functionality of proteins like Bcl-2 or survivin. SK-LMS-1 cell lysate also provides insights into the cellular metabolism changes that occur in leiomyosarcoma, offering a deeper understanding of how these cells modulate their energy production and macromolecule synthesis to support malignant growth and survival. By examining these processes, SK-LMS-1 cell lysate contributes to fundamental research in cellular and molecular biology, providing key insights into aspects of leiomyosarcoma.

SK-LMS-1 Cell Lysate References:

1. Differential Expression of IRS-1 and IRS-2 in Uterine Leiomyosarcomas with Distinct Oncogenic Phenotypes: Lack of Correlation with Downstream Signaling Events.  |  Colombatti, A., et al. 2002. Sarcoma. 6: 89-96. PMID: 18521338
2. KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.  |  Ge, W., et al. 2021. Biochem Biophys Res Commun. 570: 117-124. PMID: 34280614