SK-BR-3 Cell Lysate: sc-2218

SK-BR-3 cell lysate originates from a human breast cancer cell line, widely used in research focused on understanding the molecular and cellular mechanisms of breast cancer, particularly those that are HER2-positive. This lysate provides a vital resource for studying the overexpression of the HER2/neu protein, a prominent feature in this cell line associated with aggressive tumor growth and poor prognosis. Researchers utilize SK-BR-3 lysate to dissect signaling pathways activated by HER2, including the PI3K/Akt and MAPK pathways, which are crucial for cell proliferation and survival. Additionally, this cell lysate is instrumental in exploring mechanisms of resistance to targeted therapies, as it contains high levels of HER2 receptors. It is also used to study changes in gene expression and protein modifications that occur in response to various experimental treatments. By examining these aspects, SK-BR-3 cell lysate allows scientists to gain deeper insights into the biology of HER2-positive breast cancer, focusing strictly on cellular and molecular dynamics in research settings. This contributes significantly to the foundational knowledge in oncology, enhancing understanding of cancer cell behavior.

SK-BR-3 Cell Lysate References:

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4. In vitro synthesis of primary specific anti-breast cancer antibodies by normal human peripheral blood mononuclear cells.  |  Thakur, A., et al. 2011. Cancer Immunol Immunother. 60: 1707-20. PMID: 21713642
5. Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation.  |  Gu, GJ., et al. 2013. N Biotechnol. 30: 144-52. PMID: 22664266
6. Tyrosine 23 Phosphorylation of Annexin A2 Promotes Proliferation, Invasion, and Stat3 Phosphorylation in the Nucleus of Human Breast Cancer SK-BR-3 Cells.  |  Wang, YQ., et al. 2012. Cancer Biol Med. 9: 248-53. PMID: 23691485
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10. Bloch Surface Waves Biosensors for High Sensitivity Detection of Soluble ERBB2 in a Complex Biological Environment.  |  Sinibaldi, A., et al. 2017. Biosensors (Basel). 7: PMID: 28817097
11. Targeting Pyruvate Kinase M2 and Hexokinase II, Pachymic Acid Impairs Glucose Metabolism and Induces Mitochondrial Apoptosis.  |  Miao, G., et al. 2019. Biol Pharm Bull. 42: 123-129. PMID: 30381614
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