SJRH30 Cell Lysate: sc-2287

SJRH30 cell lysate is derived from the SJRH30 cell line, a model of human rhabdomyosarcoma, primarily used to study the biology of muscle-derived tumors in a research context. This lysate provides a crucial resource for dissecting the molecular mechanisms characteristic of rhabdomyosarcoma, particularly those involved in muscle differentiation and malignant transformation. Researchers use SJRH30 lysate to explore the regulation of key pathways such as the PAX3-FOXO1 signaling axis, which is notably altered in many rhabdomyosarcomas and affects genes related to cell cycle and apoptosis. The lysate facilitates investigations into the dysregulation of muscle-specific transcription factors and the impact of such changes on myogenic differentiation and tumor progression. It is also utilized to study the cellular response to various genetic and chemical perturbations, such as inhibition of histone deacetylases, which can influence chromatin structure and gene expression. By employing SJRH30 cell lysate, scientists gain insights into the cellular and molecular dynamics of rhabdomyosarcoma cells, contributing to a deeper understanding of tumor biology and muscle pathology.