Molecular structure of Sitagliptin phosphate monohydrate, CAS Number: 654671-77-9
Sitagliptin phosphate monohydrate (CAS 654671-77-9)
See product citations (5)
Alternate Names:
Januvia; Tesavel
Application:
Sitagliptin phosphate monohydrate is a potent, active inhibitor of DPP-IV
CAS Number:
654671-77-9
Molecular Weight:
523.32
Molecular Formula:
C16H15F6N5O•H3PO4•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Sitagliptin phosphate monohydrate is a potent inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme, which plays a role in glucose metabolism. By inhibiting this enzyme, Sitagliptin increases the levels of glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP), enhancing glucose-dependent insulin secretion from pancreatic beta cells. The increase in incretin levels also reduces glucagon secretion, which decreases hepatic glucose production. Sitagliptin′s effects on incretin hormones can be explored in various cell-based models to understand better how it modifies cellular responses to nutrients. Its role in signaling pathways that regulate insulin secretion and cell survival in pancreatic cells provides useful for diabetes research.
Sitagliptin phosphate monohydrate (CAS 654671-77-9) References
- A validated HPLC stability-indicating method for the determination of diacerhein in bulk drug substance. | Giannellini, V., et al. 2005. J Pharm Biomed Anal. 39: 776-80. PMID: 15955656
- Liquid chromatographic determination of sitagliptin either alone or in ternary mixture with metformin and sitagliptin degradation product. | El-Bagary, RI., et al. 2011. Talanta. 85: 673-80. PMID: 21645757
- Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms. | Tiţa, B., et al. 2011. J Pharm Biomed Anal. 56: 221-7. PMID: 21665404
- Simultaneous Determination of Sitagliptin Phosphate Monohydrate and Metformin Hydrochloride in Tablets by a Validated UPLC Method. | Malleswararao, CS., et al. 2012. Sci Pharm. 80: 139-52. PMID: 22396910
- Spectroflourometric and spectrophotometric methods for the determination of sitagliptin in binary mixture with metformin and ternary mixture with metformin and sitagliptin alkaline degradation product. | El-Bagary, RI., et al. 2011. Int J Biomed Sci. 7: 62-9. PMID: 23675222
- Improved Chromatographic Separation of Sitagliptin Phosphate and Metformin Hydrochloride. | Hendy, MS. 2015. Int J Biomed Sci. 11: 190-4. PMID: 26759536
- Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate. | Gao, H., et al. 2018. Molecules. 23: PMID: 29899310
- Solid-State Characterization of Different Crystalline Forms of Sitagliptin. | Stofella, NCF., et al. 2019. Materials (Basel). 12: PMID: 31344887
- Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Sitagliptin Phosphate Monohydrate. | Charoo, NA., et al. 2022. J Pharm Sci. 111: 2-13. PMID: 34597625
- Validation of a rapid and economical RP-HPLC method for simultaneous determination of metformin hydrochloride and sitagliptin phosphate monohydrate: Greenness evaluation using AGREE score. | Raza, A., et al. 2022. Pak J Pharm Sci. 35: 15-21. PMID: 35221267
- Stability of extemporaneously prepared sitagliptin phosphate solution. | Zaid, AN., et al. 2022. PLoS One. 17: e0262068. PMID: 35294449
- Understanding the Adsorption and Desorption of Sitagliptin Phosphate Monohydrate on SS2343, Glass, and PTFE Using QCM-D and Raman Spectroscopy. | Chan, HL., et al. 2022. Langmuir. 38: 10575-10584. PMID: 35984945
- A highly sensitive LC-MS/MS method for the determination and quantification of a recently identified N-nitrosamine impurity in the sitagliptin phosphate monohydrate active pharmaceutical ingredient. | Wang, Z., et al. 2023. Anal Methods. 15: 256-260. PMID: 36598084
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CD26.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sitagliptin phosphate monohydrate, 200 mg | sc-364620 | 200 mg | $63.00 |