Molecular structure of Sirtinol, CAS Number: 410536-97-9
Sirtinol (CAS 410536-97-9)
See product citations (14)
Alternate Names:
Sir Two Inhibitor Naphthol; 2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide
Application:
Sirtinol is an inhibitor of Sir2, SIRT1, and SIRT2, but not HDAC1
CAS Number:
410536-97-9
Purity:
≥97%
Molecular Weight:
394.47
Molecular Formula:
C26H22N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Sirtinol, a small molecule inhibitor, has garnered considerable attention due to its impact on biological processes such as aging. Extensive research has explored the potential applications of sirtinol across various diseases and disorders, yielding promising results in both laboratory and animal studies. Sirtinol has been examined in diverse diseases and disorders, both in experimental models and controlled laboratory environments. It exerts its effects by inhibiting the activity of Sirtuin enzymes, which play vital roles in biological processes like aging and cancer. Through this inhibition, sirtinol modulates the expression of genes involved in these intricate processes.
Sirtinol (CAS 410536-97-9) References
- Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. | Grozinger, CM., et al. 2001. J Biol Chem. 276: 38837-43. PMID: 11483616
- Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. | Koering, CE., et al. 2002. EMBO Rep. 3: 1055-61. PMID: 12393752
- Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases. | Heltweg, B., et al. 2003. Anal Biochem. 319: 42-8. PMID: 12842105
- Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. | Ota, H., et al. 2006. Oncogene. 25: 176-85. PMID: 16170353
- Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. | Mai, A., et al. 2005. J Med Chem. 48: 7789-95. PMID: 16302818
- Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. | Orecchia, A., et al. 2011. PLoS One. 6: e24307. PMID: 21931678
- Sirtuin activators and inhibitors. | Villalba, JM. and Alcaín, FJ. 2012. Biofactors. 38: 349-59. PMID: 22730114
- Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. | Wang, J., et al. 2012. Int J Oncol. 41: 1101-9. PMID: 22751989
- Sirtinol attenuates trauma hemorrhage-induced hepatic injury through Akt-dependent pathway in rats. | Liu, FC., et al. 2013. J Trauma Acute Care Surg. 74: 1027-32. PMID: 23511141
- Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. | Tsai, YF., et al. 2015. Sci Rep. 5: 8347. PMID: 25666548
- Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2. | Zhang, M., et al. 2017. Sci Rep. 7: 7. PMID: 28127057
- Sirtinol, a Sir2 protein inhibitor, affects stem cell maintenance and root development in Arabidopsis thaliana by modulating auxin-cytokinin signaling components. | Singh, S., et al. 2017. Sci Rep. 7: 42450. PMID: 28195159
- Sirtinol regulates the balance of Th17/Treg to prevent allograft rejection. | Ye, Q., et al. 2017. Cell Biosci. 7: 55. PMID: 29090089
- Sirtinol Supresses Trophozoites Proliferation and Encystation of Acanthamoeba via Inhibition of Sirtuin Family Protein. | Joo, SY., et al. 2022. Korean J Parasitol. 60: 1-6. PMID: 35247948
Inhibitor of:
1200013P24Rik, A530032D15Rik, Abp ζ, ANKRD11, ART1, ART2A, ART3, Ataxin-7, ATF-7, ELP4, ESCO1, FOXK2, H2al3, HBO1, HIGD1C, Histone cluster 1 H1D, Histone cluster 1 H3E, Histone cluster 1 H3I, Histone cluster 1 H4H, Histone H2A.V, Histone H2A.X, lysine, mage-k1, MIBP, MYBBP1A, NAA (N-alpha-acetyltransferase), NAT-11, NAT-13, NMNAT-3, p53AIP1, PHGR1, PWWP2B, RbAp48, RIZ, SG2NA, Sir2, Sir3, SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT7, SMARCD2, SMCHD1, TAF II p28, TBC1D24, TMEM103, Trp53i11, YBEY, and ZBP-89.Activator of:
ADA3, ARH3, ATXN7L2, BAFL, BAHD1, BC030500, BPTF, EFO2, EID-1, Gfi-1B, H1T2, H2AL2, H2al2y, HAT1, Histone cluster 1 H2AH, Histone cluster 1 H2AO, Histone cluster 1 H3F, Histone cluster 1 H4, Histone cluster 1 H4M, Histone cluster 3 H2A, Jade-1, JMY, MacroH2A, MAGE-G2, Med10, Mxi1, NAT-12, pan-Acetyl, Sec24, SENP2, Sir4, SIRT6, SMC3, Smt3, Swi1, Swi3, and WSTF.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sirtinol, 1 mg | sc-205976 | 1 mg | $38.00 | |||
Sirtinol, 5 mg | sc-205976A | 5 mg | $113.00 |