Molecular structure of SIRT1 Activator 3, CAS Number: 839699-72-8
SIRT1 Activator 3 (CAS 839699-72-8)
See product citations (8)
Alternate Names:
Sirtuin 1 Activator 3
Application:
SIRT1 Activator 3 is a SIRT1 activator which also inhibits TNF-α
CAS Number:
839699-72-8
Molecular Weight:
367.44
Molecular Formula:
C20H25N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SIRT1 Activator 3 is a member of the sirtuins (SIRTs), a distinctive class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been illustrated to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. This compound may act to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-alpha in a dose-dependent manner. In THP-1 cells, TNF-alpha levels decreased from 325 rhog/ml (control) to 104 and 53 rhog/ml with 20 and 60 muM of SIRT1 Activator 3, respectively. This activator also has shown a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which indicates the potential of SIRT1 activators for obesity research, and may inhibit neurotoxicity of the prion protein.
SIRT1 Activator 3 (CAS 839699-72-8) References
- SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. | Nayagam, VM., et al. 2006. J Biomol Screen. 11: 959-67. PMID: 17099246
- SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death. | Seo, JS., et al. 2012. Neurobiol Aging. 33: 1110-20. PMID: 21074897
- Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner. | Barbieri, SS., et al. 2012. Circulation. 126: 1373-84. PMID: 22865892
- The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC). | Thompson, KJ., et al. 2015. Adv Exp Med Biol. 815: 361-73. PMID: 25427918
- Production of prostaglandin E2 induced by cigarette smoke modulates tissue factor expression and activity in endothelial cells. | Amadio, P., et al. 2015. FASEB J. 29: 4001-10. PMID: 26065856
- Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes. | Tong, X., et al. 2015. PLoS One. 10: e0130047. PMID: 26075729
- Sirtuin 1 modulation in rat model of acetaminophen-induced hepatotoxicity. | Wojnarová, L., et al. 2015. Physiol Res. 64: S477-S487. PMID: 26681077
- BDNFVal66met polymorphism: a potential bridge between depression and thrombosis. | Amadio, P., et al. 2017. Eur Heart J. 38: 1426-1435. PMID: 26705390
- The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3. | Li, Z., et al. 2017. Oncogene. 36: 1887-1898. PMID: 27669435
- Sirtuin-activating compounds (STACs) alleviate D-galactosamine/lipopolysaccharide-induced hepatotoxicity in rats: involvement of sirtuin 1 and heme oxygenase 1. | Kemelo, MK., et al. 2017. Physiol Res. 66: 497-505. PMID: 28248534
- CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells. | Murofushi, T., et al. 2017. J Oral Sci. 59: 415-423. PMID: 28904318
- NLRX1 Modulates Immunometabolic Mechanisms Controlling the Host-Gut Microbiota Interactions during Inflammatory Bowel Disease. | Leber, A., et al. 2018. Front Immunol. 9: 363. PMID: 29535731
- One-pot synthesis of biologically active 1,2,3-trisubstituted pyrrolo[2,3-b]quinoxalines through a palladium-catalyzed reaction with internal alkyne moieties. | Keivanloo, A., et al. 2018. Mol Divers. 22: 879-891. PMID: 29909566
- Engineering Lineage Potency and Plasticity of Stem Cells using Epigenetic Molecules. | Dhaliwal, A., et al. 2018. Sci Rep. 8: 16289. PMID: 30389989
- Protein Kinase CK2 Maintains Reciprocal Balance Between Th17 and Treg Cells in the Pathogenesis of UC. | Dong, G., et al. 2022. Inflamm Bowel Dis. 28: 830-842. PMID: 34904630
Inhibitor of:
Apoptosis, and TNF alpha.Activator of:
SIRT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SIRT1 Activator 3, 1 mg | sc-222315 | 1 mg | $106.00 | |||
SIRT1 Activator 3, 5 mg | sc-222315A | 5 mg | $363.00 | |||
SIRT1 Activator 3, 10 mg | sc-222315B | 10 mg | $640.00 | |||
SIRT1 Activator 3, 25 mg | sc-222315C | 25 mg | $1397.00 |