Sinomenine hydrochloride (CAS 6080-33-7)

Sinomenine hydrochloride, an alkaloid derived from Sinomenium acutum, has attracted attention in scientific research for its diverse pharmacological properties. Its mechanism of action includes the inhibition of inflammatory mediators such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and prostaglandin E2 (PGE2). Additionally, sinomenine hydrochloride modulates immune responses by suppressing the activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways, leading to a reduction in inflammatory cytokine production. Furthermore, it exhibits analgesic effects by interfering with the transmission of pain signals through inhibition of calcium channels and N-methyl-D-aspartate (NMDA) receptors. In research, sinomenine hydrochloride has been studied for its potential applications in various contexts, including exploring its effects on cellular signaling pathways and investigating its role in modulating cellular responses to external stimuli. Its multifaceted pharmacological profile makes sinomenine hydrochloride a valuable tool for understanding fundamental biological mechanisms and exploring potential applications in scientific research.