Molecular structure of Sinomenine, CAS Number: 115-53-7
Sinomenine (CAS 115-53-7)
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Alternate Names:
Coculine; Kukoline; Sabianine A
Application:
Sinomenine is a chemical that inhibits microglia activation and could thus potential attenuate brain injury in intracerebral hemorrhage
CAS Number:
115-53-7
Purity:
≥98%
Molecular Weight:
329.39
Molecular Formula:
C19H23NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sinomenine is a alkaloid compound that exhibits anti-inflammatory and immunosuppressive properties. It functions by inhibiting the production of pro-inflammatory cytokines and modulating the activity of immune cells, such as T cells and macrophages. At the molecular level, sinomenine suppresses the activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Sinomenine also interferes with the function of toll-like receptors (TLRs), which play a key role in the initiation of immune responses. Sinomenine′s mechanism of action involves the regulation of various molecular targets involved in the inflammatory and immune response processes, making it useful for investigating these pathways in experimental applications.
Sinomenine (CAS 115-53-7) References
- Sinomenine improve diabetic nephropathy by inhibiting fibrosis and regulating the JAK2/STAT3/SOCS1 pathway in streptozotocin-induced diabetic rats. | Zhu, M., et al. 2021. Life Sci. 265: 118855. PMID: 33278392
- Suppression of macrophage migration by down-regulating Src/FAK/P130Cas activation contributed to the anti-inflammatory activity of sinomenine. | Gao, WJ., et al. 2021. Pharmacol Res. 167: 105513. PMID: 33617975
- Sinomenine ameliorates septic acute lung injury in mice by modulating gut homeostasis via aryl hydrocarbon receptor/Nrf2 pathway. | Song, W., et al. 2021. Eur J Pharmacol. 912: 174581. PMID: 34743979
- Sinomenine Inhibits the Progression of Bladder Cancer Cells by Downregulating LncRNA-HEIH Expression. | Xu, H., et al. 2021. Evid Based Complement Alternat Med. 2021: 4699529. PMID: 34760016
- Sinomenine ameliorates cardiac hypertrophy by activating Nrf2/ARE signaling pathway. | Yuan, M., et al. 2021. Bioengineered. 12: 12778-12788. PMID: 34895050
- Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway. | Zheng, X., et al. 2021. Acta Pharm Sin B. 11: 3465-3480. PMID: 34900530
- Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis. | Song, L., et al. 2022. Biomed Res Int. 2022: 4914005. PMID: 35309179
- Sinomenine inhibits macrophage M1 polarization by downregulating α7nAChR via a feedback pathway of α7nAChR/ERK/Egr-1. | Zhi, YK., et al. 2022. Phytomedicine. 100: 154050. PMID: 35397284
- Multifunctional nanoparticles of sinomenine hydrochloride for treat-to-target therapy of rheumatoid arthritis via modulation of proinflammatory cytokines. | Lin, Y., et al. 2022. J Control Release. 348: 42-56. PMID: 35569587
- Sinomenine alleviates glomerular endothelial permeability by activating the C/EBP-α/claudin-5 signaling pathway. | Zhang, L. and Wang, J. 2022. Hum Cell. 35: 1453-1463. PMID: 35854195
- Sinomenine Suppressed Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis by Regulating lncRNA XIST. | Xiang, S., et al. 2022. Skin Pharmacol Physiol. 35: 328-342. PMID: 35960313
- Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs. | Li, H., et al. 2022. Drug Des Devel Ther. 16: 2949-2965. PMID: 36090955
- Sinomenine pretreatment alleviates hepatic ischemia/reperfusion injury through activating Nrf-2/HO-1 pathway. | Hui, B., et al. 2022. Immun Inflamm Dis. 10: e700. PMID: 36169257
- Sinomenine attenuates lipopolysaccharide-induced inflammation and apoptosis of WI-38 cells by reducing glutathione S-transferase M1 expression. | Liu, Y., et al. 2022. Chem Biol Drug Des.. PMID: 36303295
- Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways. | Potočnjak, I., et al. 2023. Food Chem Toxicol. 171: 113538. PMID: 36455684
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sinomenine, 100 mg | sc-224285 | 100 mg | $54.00 |