Molecular structure of Simvastatin, Sodium Salt, CAS Number: 12009-77-6
Simvastatin, Sodium Salt (CAS 12009-77-6)
See product citations (6)
Alternate Names:
Simvastatin hydroxy acid sodium salt
Application:
Simvastatin, Sodium Salt is an HMGCR inhibitor
CAS Number:
12009-77-6
Molecular Weight:
458.57
Molecular Formula:
C25H39O6•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Simvastatin, Sodium Salt is a synthetic compound that belongs to a class of substances known as statins. It is referenced as a standard or control substance when studying the biochemical pathways involving HMG-CoA reductase, an enzyme critical to cholesterol biosynthesis. Additionally, the impact of Simvastatin on various cellular processes beyond its primary target is a subject of ongoing research, contributing to a broader understanding of cellular metabolism and biochemistry. The compound′s properties are also investigated in the context of its physicochemical behavior, stability, and solubility, which are relevant for the development of analytical methods in chemical sciences.
Simvastatin, Sodium Salt (CAS 12009-77-6) References
- Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. | Yada, T., et al. 1999. Br J Pharmacol. 126: 1205-13. PMID: 10205010
- Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. | Grahek, R., et al. 2001. J Chromatogr A. 918: 319-24. PMID: 11407578
- Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. | Keyomarsi, K., et al. 1991. Cancer Res. 51: 3602-9. PMID: 1711413
- Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum. | Pradines, B., et al. 2007. Antimicrob Agents Chemother. 51: 2654-5. PMID: 17502414
- The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. | Glynn, SA., et al. 2008. BMC Cancer. 8: 9. PMID: 18199328
- Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity. | Xie, X., et al. 2009. Biotechnol Bioeng. 102: 20-8. PMID: 18988191
- Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein. | Marsh, A., et al. 2016. PLoS One. 11: e0148266. PMID: 26863535
- Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells. | Kässner, F., et al. 2018. Int J Mol Med. 41: 3691-3698. PMID: 29568880
- Simvastatin-sodium delays cell death of anoxic cardiomyocytes by inhibition of the Na+/Ca2+ exchanger. | Bastiaanse, EM., et al. 1994. FEBS Lett. 343: 151-4. PMID: 8168621
- Effects of different inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, pravastatin sodium and simvastatin, on sterol synthesis and immunological functions in human lymphocytes in vitro. | Kurakata, S., et al. 1996. Immunopharmacology. 34: 51-61. PMID: 8880225
- Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types. | Nègre-Aminou, P., et al. 1997. Biochim Biophys Acta. 1345: 259-68. PMID: 9150246
- Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21ras activated, AP-1-dependent pathway. | Vrtovsnik, F., et al. 1997. Kidney Int. 52: 1016-27. PMID: 9328940
- Inhibitory effect of simvastatin on the proliferation of human myeloid leukaemia cells in severe combined immunodeficient (SCID) mice. | Clutterbuck, RD., et al. 1998. Br J Haematol. 102: 522-7. PMID: 9695968
Inhibitor of:
HMGCR, and MARCH (membrane associated ring-CH-type finger).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Simvastatin, Sodium Salt, 5 mg | sc-222312 | 5 mg | $162.00 |