Molecular structure of Simvastatin Hydroxy Acid Sodium Salt, CAS Number: 101314-97-0
Simvastatin Hydroxy Acid Sodium Salt (CAS 101314-97-0)
See product citations (2)
Alternate Names:
Simvastatin Sodium; Simvastatin Sodium Salt
Application:
Simvastatin Hydroxy Acid Sodium Salt is Simvastatin Hydroxy Acid Sodium Salt is an inhibitor of HMGCR.
CAS Number:
101314-97-0
Molecular Weight:
458.56
Molecular Formula:
C25H39O6•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Simvastatin Hydroxy Acid Sodium Salt, the active metabolite of simvastatin, is a compound primarily used in biochemical research focused on cholesterol biosynthesis and lipid metabolism. In the laboratory, it serves as a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the key enzyme responsible for the production of cholesterol. Exploration of its inhibitory effects helps researchers to understand the regulation of cholesterol synthesis at the molecular level and the impact on lipid homeostasis within cells. The sodium salt form enhances its solubility in aqueous solutions, facilitating its use in various experimental setups. Additionally, this compound is used in studies investigating the non-cholesterol-related effects of HMG-CoA reductase inhibition, including protein prenylation and cell signaling pathways.
Simvastatin Hydroxy Acid Sodium Salt (CAS 101314-97-0) References
- Structural characterization of in vivo rat glutathione adducts and a hydroxylated metabolite of simvastatin hydroxy acid. | Subramanian, R., et al. 2002. Drug Metab Dispos. 30: 225-30. PMID: 11854137
- Interconversion pharmacokinetics of simvastatin and its hydroxy acid in dogs: effects of gemfibrozil. | Prueksaritanont, T., et al. 2005. Pharm Res. 22: 1101-9. PMID: 16028010
- Study on the conversion of three natural statins from lactone forms to their corresponding hydroxy acid forms and their determination in Pu-Erh tea. | Yang, DJ. and Hwang, LS. 2006. J Chromatogr A. 1119: 277-84. PMID: 16388814
- Use of a green (bio) solvent--limonene--as extractant and immiscible diluent for large volume injection in the RPLC-tandem MS assay of statins and related metabolites in human plasma. | Medvedovici, A., et al. 2013. Biomed Chromatogr. 27: 48-57. PMID: 22511331
- Poloxamine-cyclodextrin-simvastatin supramolecular systems promote osteoblast differentiation of mesenchymal stem cells. | Simões, SM., et al. 2013. Macromol Biosci. 13: 723-34. PMID: 23610048
- Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression. | Clarke, JD., et al. 2014. J Pharmacol Exp Ther. 348: 452-8. PMID: 24403518
- Simultaneous quantification of simvastatin and simvastatin hydroxy acid in blood serum at physiological pH by ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC/MS/MS). | Bews, HJ., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 947-948: 145-50. PMID: 24424299
- Validated UPLC-MS/MS method for simultaneous determination of simvastatin, simvastatin hydroxy acid and berberine in rat plasma: Application to the drug-drug pharmacokinetic interaction study of simvastatin combined with berberine after oral administration in rats. | Liu, M., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 1006: 8-15. PMID: 26519618
- Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study. | Patel, YT., et al. 2016. Drug Metab Dispos. 44: 591-4. PMID: 26802130
- In vitro antibacterial effects of statins against bacterial pathogens causing skin infections. | Ko, HHT., et al. 2018. Eur J Clin Microbiol Infect Dis. 37: 1125-1135. PMID: 29569046
- Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model. | Fan, X., et al. 2020. Acta Pharm Sin B. 10: 123-135. PMID: 31993311
- Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach. | Barbarossa, A., et al. 2022. Antibiotics (Basel). 11: PMID: 35740222
- Microsample determination of lovastatin and its hydroxy acid metabolite in mouse and rat plasma by liquid chromatography/ionspray tandem mass spectrometry. | Wu, Y., et al. 1997. J Mass Spectrom. 32: 379-87. PMID: 9130396
Inhibitor of:
HMGCR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Simvastatin Hydroxy Acid Sodium Salt, 1 mg | sc-473941B | 1 mg | $141.00 | |||
Simvastatin Hydroxy Acid Sodium Salt, 5 mg | sc-473941C | 5 mg | $223.00 | |||
Simvastatin Hydroxy Acid Sodium Salt, 10 mg | sc-473941 | 10 mg | $297.00 | |||
Simvastatin Hydroxy Acid Sodium Salt, 25 mg | sc-473941A | 25 mg | $577.00 | |||
Simvastatin Hydroxy Acid Sodium Salt, 100 mg | sc-473941D | 100 mg | $2002.00 |