Simvastatin-d6 (CAS 1002347-71-8)
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Simvastatin-d6 is a deuterium-labeled version of simvastatin, employed in the field of analytical chemistry for stable isotope-labeled mass spectrometric studies. During in vitro research applications it serves as an internal standard to ensure accuracy and precision in the quantification of simvastatin within complex biological matrices, such as blood or liver microsomes. The presence of deuterium atoms minimally alters the physical properties of the compound, allowing for a near-identical retention time and behavior in chromatographic systems, which is for method validation in bioanalytical assays. Researchers also use simvastatin-d6 in studies of chemical metabolism to track the compound′s biotransformation and to understand the enzyme kinetics involved in its metabolic pathway. Additionally, environmental scientists may employ this labeled compound to investigate the persistence and degradation of statins in aquatic environments, assessing their impact on ecosystems.
Simvastatin-d6 (CAS 1002347-71-8) References
- Ultra high performance liquid chromatography tandem mass spectrometric detection in clinical analysis of simvastatin and atorvastatin. | Nováková, L., et al. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 2093-103. PMID: 19540175
- Multi-residue analytical method for human pharmaceuticals and synthetic hormones in river water and sewage effluents by solid-phase extraction and liquid chromatography-tandem mass spectrometry. | Al-Odaini, NA., et al. 2010. J Chromatogr A. 1217: 6791-806. PMID: 20851398
- Use of ultra high performance liquid chromatography-tandem mass spectrometry to demonstrate decreased serum statin levels after extracorporeal LDL-cholesterol elimination. | Bláha, M., et al. 2011. J Biomed Biotechnol. 2011: 912472. PMID: 21076535
- Removal of trace organic chemical contaminants by a membrane bioreactor. | Trinh, T., et al. 2012. Water Sci Technol. 66: 1856-63. PMID: 22925856
- Reduced exposure variability of the CYP3A substrate simvastatin by dose individualization to CYP3A activity. | Stoll, F., et al. 2013. J Clin Pharmacol. 53: 1199-204. PMID: 23939663
- Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression. | Clarke, JD., et al. 2014. J Pharmacol Exp Ther. 348: 452-8. PMID: 24403518
- Pharmacokinetic interaction between simvastatin and fenofibrate with staggered and simultaneous dosing: Does it matter? | Winsemius, A., et al. 2014. J Clin Pharmacol. 54: 1038-47. PMID: 24691799
- Occurrence and daily variability of pharmaceuticals and personal care products in swimming pools. | Teo, TL., et al. 2016. Environ Sci Pollut Res Int. 23: 6972-81. PMID: 26705754
- Micro-SPE in pipette tips as a tool for analysis of small-molecule drugs in serum. | Vlčková, H., et al. 2017. Bioanalysis. 9: 887-901. PMID: 28617093
- Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine. | Buchanan, B., et al. 2018. PLoS One. 13: e0194979. PMID: 29579096
- Extraction and cleansing of data for a non-targeted analysis of high-resolution mass spectrometry data of wastewater. | Verkh, Y., et al. 2018. MethodsX. 5: 395-402. PMID: 30050758
- A multi-residue analytical method for extraction and analysis of pharmaceuticals and other selected emerging contaminants in sewage sludge. | Riva, F., et al. 2021. Anal Methods. 13: 526-535. PMID: 33447838
- Genomewide Association Study of Simvastatin Pharmacokinetics. | Mykkänen, AJH., et al. 2022. Clin Pharmacol Ther. 112: 676-686. PMID: 35652242
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Simvastatin-d6, 2.5 mg | sc-220104 | 2.5 mg | $353.00 |