SIM2s Antibody (3E6): sc-517035

SIM2s Antibody (3E6) is a mouse monoclonal IgG2a kappa light chain antibody that detects SIM2s protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SIM2s antibody (3E6) is available as a non-conjugated isotype antibody. SIM2s protein plays a crucial role in gene expression regulation during development, particularly in the context of the Per-Arnt-Sim (PAS) domain, a 270 amino acid motif that facilitates interactions among various PAS family transcription factors. SIM2s protein is essential for proper functioning of the aromatic hydrocarbon receptor (AhR) and its partner, the Ah receptor nuclear translocator protein 1 (Arnt 1), which are involved in mediating cellular responses to environmental signals. SIM2 protein can inhibit AhR and Arnt 1 dimerization, thereby regulating transcriptional activation and influencing developmental processes. SIM2s significance extends to potential involvement in Down syndrome, as SIM2s is located on chromosome 21 and may contribute to developmental anomalies associated with this condition. Anti-SIM2s antibody (3E6) enables valuable insights into molecular mechanisms underlying gene regulation and developmental biology.

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SIM2s Antibody (3E6) References:

1. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.  |  Reyes, H., et al. 1992. Science. 256: 1193-5. PMID: 1317062
2. Transcriptional activation domains of the Ah receptor and Ah receptor nuclear translocator.  |  Sogawa, K., et al. 1995. J Cancer Res Clin Oncol. 121: 612-20. PMID: 7559746
3. PAS is a dimerization domain common to Drosophila period and several transcription factors.  |  Huang, ZJ., et al. 1993. Nature. 364: 259-62. PMID: 8391649
4. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.  |  Fan, CM., et al. 1996. Mol Cell Neurosci. 7: 1-16. PMID: 8812055
5. Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis.  |  Ema, M., et al. 1996. Mol Cell Biol. 16: 5865-75. PMID: 8927054
6. Ah receptor, a novel ligand-activated transcription factor.  |  Sogawa, K. and Fujii-Kuriyama, Y. 1997. J Biochem. 122: 1075-9. PMID: 9498548