Molecular structure of Silychristin
Silychristin (CAS 33889-69-9)
Alternate Names:
Silymarin II
Application:
Silychristin is an analytical standard
CAS Number:
33889-69-9
Molecular Weight:
482.44
Molecular Formula:
C25H22O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Silychristin, a naturally occurring flavonoid belonging to the flavonoid family, is primarily found in Silybum marianum, known as milk thistle. While the precise mechanism of action of silychristin remains elusive, it is postulated to function through the scavenging of free radicals and the inhibition of specific enzymes. Moreover, silychristin has been observed to inhibit the activity of certain transcription factors. Silychristin as a member of the flavonoid group exhibits potential properties that could be used in a diverse range of biochemical activities.
Silychristin (CAS 33889-69-9) References
- Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry. | Lee, JI., et al. 2006. J Chromatogr A. 1116: 57-68. PMID: 16631762
- Silymarin and its components scavenge phenylglyoxylic ketyl radicals. | Sersen, F., et al. 2006. Fitoterapia. 77: 525-9. PMID: 16956731
- Regioselective alcoholysis of silychristin acetates catalyzed by lipases. | Vavříková, E., et al. 2015. Int J Mol Sci. 16: 11983-95. PMID: 26016503
- Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity. | Pyszková, M., et al. 2016. Free Radic Biol Med. 90: 114-25. PMID: 26582372
- Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. | Johannes, J., et al. 2016. Endocrinology. 157: 1694-701. PMID: 26910310
- Silychristin: Skeletal Alterations and Biological Activities. | Biedermann, D., et al. 2016. J Nat Prod. 79: 3086-3092. PMID: 28006905
- Metabolism of flavonolignans in human hepatocytes. | Vrba, J., et al. 2018. J Pharm Biomed Anal. 152: 94-101. PMID: 29414024
- Silychristin derivatives conjugated with coniferylalcohols from silymarin and their pancreatic α-amylase inhibitory activity. | Kato, E., et al. 2020. Nat Prod Res. 34: 759-765. PMID: 30445852
- Differential Effects of the Flavonolignans Silybin, Silychristin and 2,3-Dehydrosilybin on Mesocestoides vogae Larvae (Cestoda) under Hypoxic and Aerobic In Vitro Conditions. | Hrčková, G., et al. 2018. Molecules. 23: PMID: 30453549
- Skin Protective Activity of Silymarin and its Flavonolignans. | Vostálová, J., et al. 2019. Molecules. 24: PMID: 30875758
- A pilot study of the UVA-photoprotective potential of dehydrosilybin, isosilybin, silychristin, and silydianin on human dermal fibroblasts. | Rajnochová Svobodová, A., et al. 2019. Arch Dermatol Res. 311: 477-490. PMID: 31079190
- Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans. | Vrba, J., et al. 2020. J Pharm Biomed Anal. 178: 112972. PMID: 31727359
- Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota. | Valentová, K., et al. 2020. Metabolites. 10: PMID: 31936497
- Development of a capillary electrophoresis method for the separation of flavonolignans in silymarin complex. | Riasová, P., et al. 2022. Electrophoresis. 43: 930-938. PMID: 34751959
- System biology-based investigation of Silymarin to trace hepatoprotective effect. | Dwivedi, PSR., et al. 2022. Comput Biol Med. 142: 105223. PMID: 35033877
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Silychristin, 5 mg | sc-473920A | 5 mg | $235.00 | |||
Silychristin, 10 mg | sc-473920 | 10 mg | $456.00 | |||
Silychristin, 25 mg | sc-473920B | 25 mg | $516.00 |