Date published: 2026-4-25

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Silybin B (CAS 142797-34-0)

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Alternate Names:
(2R,3R)-2-[(2S,3S)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; 1,4-Benzodioxin, 4H-1-benzopyran-4-one deriv.; Silibinin B
CAS Number:
142797-34-0
Molecular Weight:
482.44
Molecular Formula:
C25H22O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Silybin B, a prominent flavonolignan component found in the milk thistle plant (Silybum marianum), plays a pivotal role in the field of biochemical research, particularly in studies related to liver health and cellular protection mechanisms. Its molecular structure facilitates a unique interaction with cellular membranes and enzymes, modulating their activity and thereby influencing the cellular defense systems against oxidative stress. Silybin B′s mechanism of action involves the inhibition of lipid peroxidation and enhancement of the antioxidant enzyme systems, which are for maintaining the integrity of cellular components and preventing damage from reactive oxygen species (ROS). Furthermore, its ability to modulate signaling pathways that govern cell survival and apoptosis positions Silybin B as useful in the exploration of cellular responses to oxidative stress and the potential restoration of cellular homeostasis. Through these interactions, Silybin B contributes significantly to the understanding of the molecular bases of cellular protection and the body′s natural defense mechanisms, making it a subject of interest in biochemical and pharmacological research circles that focus on the fundamental aspects of cellular resilience and health.


Silybin B (CAS 142797-34-0) References

  1. Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, Isolated from Silybum marianum (milk thistle).  |  Lee, DY. and Liu, Y. 2003. J Nat Prod. 66: 1171-4. PMID: 14510591
  2. Stereoselective metabolism of silybin diastereoisomers in the glucuronidation process.  |  Han, YH., et al. 2004. J Pharm Biomed Anal. 34: 1071-8. PMID: 15019041
  3. Microbial transformation of silybin by Trichoderma koningii.  |  Kim, HJ., et al. 2006. Bioorg Med Chem Lett. 16: 790-3. PMID: 16309908
  4. Enzymatic kinetic resolution of silybin diastereoisomers.  |  Monti, D., et al. 2010. J Nat Prod. 73: 613-9. PMID: 20297826
  5. A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells.  |  Zhang, J., et al. 2011. Nat Prod Commun. 6: 1653-6. PMID: 22224281
  6. Enhanced bioactivity of silybin B methylation products.  |  Sy-Cordero, AA., et al. 2013. Bioorg Med Chem. 21: 742-7. PMID: 23260576
  7. Enzymatic preparation of silybin phase II metabolites: sulfation using aryl sulfotransferase from rat liver.  |  Purchartová, K., et al. 2013. Appl Microbiol Biotechnol. 97: 10391-8. PMID: 23494622
  8. Chemistry of silybin.  |  Biedermann, D., et al. 2014. Nat Prod Rep. 31: 1138-57. PMID: 24977260
  9. Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study.  |  Li, WY., et al. 2018. Clin Ther. 40: 103-113.e1. PMID: 29273470
  10. Silybin B and Cianidanol Inhibit Mpro and Spike Protein of SARS-CoV-2: Evidence from in silico Molecular Docking Studies.  |  Srivastava, R., et al. 2021. Curr Pharm Des. 27: 3476-3489. PMID: 33302853
  11. Recapitulation of Evidence of Phytochemical, Pharmacokinetic and Biomedical Application of Silybin.  |  Islam, A., et al. 2021. Drug Res (Stuttg). 71: 489-503. PMID: 34318464
  12. Investigation on the solid-phase synthesis of silybin prodrugs and their timed-release.  |  Romanucci, V., et al. 2021. Bioorg Med Chem. 50: 116478. PMID: 34695708
  13. Silybin B exerts protective effect on cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis.  |  Wang, XL., et al. 2022. J Ethnopharmacol. 288: 114938. PMID: 34999144
  14. Silybins inhibit human IAPP amyloid growth and toxicity through stereospecific interactions.  |  García-Viñuales, S., et al. 2022. Biochim Biophys Acta Proteins Proteom. 1870: 140772. PMID: 35307557
  15. Inhibition of UGT1A1*1 and UGT1A1*6 catalyzed glucuronidation of SN-38 by silybins.  |  Li, W., et al. 2022. Chem Biol Interact. 368: 110248. PMID: 36343684

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Silybin B, 5 mg

sc-472757
5 mg
$595.00