Molecular structure of Sildenafil-d3, CAS Number: 1126745-90-1
Sildenafil-d3 (CAS 1126745-90-1)
Application:
Sildenafil-d3 is a deuterium-labelled analog of Sildenafil
CAS Number:
1126745-90-1
Molecular Weight:
477.60
Molecular Formula:
C22H27D3N6O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sildenafil-d3 is a deuterium-labelled analog of Sildenafil (sc-338584). Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.
Sildenafil-d3 (CAS 1126745-90-1) References
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- Suspended solids moderate the degradation and sorption of waste water-derived pharmaceuticals in estuarine waters. | Aminot, Y., et al. 2018. Sci Total Environ. 612: 39-48. PMID: 28850851
- Large scale micropollutants and lipids screening in the sludge layers and the ecosystem of a vertical flow constructed wetland. | Maurer, L., et al. 2020. Sci Total Environ. 746: 141196. PMID: 32771759
- Distribution and degradation trend of micropollutants in a surface flow treatment wetland revealed by 3D numerical modelling combined with LC-MS/MS. | Maurer, L., et al. 2021. Water Res. 190: 116672. PMID: 33285453
- Treatment of Cardiovascular Dysfunction With PDE5-Inhibitors - Temperature Dependent Effects on Transport and Metabolism of cAMP and cGMP. | Selli, AL., et al. 2021. Front Physiol. 12: 695779. PMID: 34393818
- Breast Cancer Resistance Protein Limits Fetal Transfer of Tadalafil in Mice. | Nishimura, T., et al. 2024. J Pharm Sci. 113: 486-492. PMID: 37981232
Inhibitor of:
PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sildenafil-d3, 1 mg | sc-220101 | 1 mg | $300.00 |