Siglec-10 Antibody (1D11): sc-293355

Siglec-10 Antibody (1D11) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Siglec-10 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Siglec-10 antibody (1D11) is available as the non-conjugated format. Siglec-10, or Sialic acid-binding Ig-like lectin 10, is a 697 amino acid protein that plays a crucial role in the immune system as an inhibitory receptor. Siglec-10 is primarily expressed in the spleen, bone marrow, and peripheral blood lymphocytes, including monocytes, natural killer cells, and eosinophils. Siglec-10 features an N-terminal Ig-like domain with a sialic acid-binding site, which is essential for interaction with sialic acid-containing ligands, and a C-terminal cytoplasmic region that contains two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). These motifs are critical for modulating cellular responses through the recruitment of SH2 domain-containing proteins, thereby influencing immune signaling pathways. Notably, Siglec-10 mRNA is significantly upregulated in eosinophils at sites of inflammation in asthmatics, indicating potential as a therapeutic target for immunomodulatory strategies. Additionally, six named isoforms of Siglec-10 result from alternative splicing, with all isoforms existing as single-pass transmembrane proteins, except for isoform 6, which is secreted.

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Siglec-10 Antibody (1D11) References:

1. Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor.  |  Munday, J., et al. 2001. Biochem J. 355: 489-97. PMID: 11284738
2. Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells.  |  Li, N., et al. 2001. J Biol Chem. 276: 28106-12. PMID: 11358961
3. Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants.  |  Yousef, GM., et al. 2001. Biochem Biophys Res Commun. 284: 900-10. PMID: 11409878
4. A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33.  |  Whitney, G., et al. 2001. Eur J Biochem. 268: 6083-96. PMID: 11733002
5. Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1.  |  Kitzig, F., et al. 2002. Biochem Biophys Res Commun. 296: 355-62. PMID: 12163025
6. Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).  |  Aizawa, H., et al. 2003. Genomics. 82: 521-30. PMID: 14559209

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Siglec-10 Antibody (1D11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Siglec-10 Antibody (1D11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Siglec-10 Antibody (1D11) Specifications

Alternate Product Name: Siglec-10

Product Clone Name: 1D11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 589-696

Epitope Target: Siglec-10

Epitope Species: human

Product Reactivity/Detection: Siglec-10

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Siglec-10 Antibody (1D11): N/A