Molecular structure of SID 7969543, CAS Number: 868224-64-0
SID 7969543 (CAS 868224-64-0)
Alternate Names:
2-[2-[(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YLCARBAMOYL)METHYL]-1-OXO-1,2-DIHYDROISOQUINOLIN-5-YLOXY]PROPIONIC ACID ETHYL ESTER
Application:
SID 7969543 is a selective SF-1 inhibitor
CAS Number:
868224-64-0
Molecular Weight:
452.46
Molecular Formula:
C24H24N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM).
SID 7969543 (CAS 868224-64-0) References
- Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. | Madoux, F., et al. 2008. Mol Pharmacol. 73: 1776-84. PMID: 18334597
- Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. | Roth, J., et al. 2008. Bioorg Med Chem Lett. 18: 2628-32. PMID: 18374567
- Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists. | Doghman, M., et al. 2009. J Clin Endocrinol Metab. 94: 2178-83. PMID: 19318454
- Identification and characterization of steroidogenic factor-1 inverse agonists. | Doghman, M., et al. 2010. Methods Enzymol. 485: 3-23. PMID: 21050908
- New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma (Review). | Stigliano, A., et al. 2017. Oncol Rep. 37: 1301-1311. PMID: 28184938
- Oocyte-Derived Factors (GDF9 and BMP15) and FSH Regulate AMH Expression Via Modulation of H3K27AC in Granulosa Cells. | Roy, S., et al. 2018. Endocrinology. 159: 3433-3445. PMID: 30060157
- Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors. | D'Agostino, EH., et al. 2020. ACS Med Chem Lett. 11: 365-370. PMID: 32184971
- Orphan nuclear receptors as regulators of intratumoral androgen biosynthesis in castration-resistant prostate cancer. | Zhou, J., et al. 2021. Oncogene. 40: 2625-2634. PMID: 33750894
- Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia. | Karsa, M., et al. 2021. Front Oncol. 11: 779859. PMID: 35127484
- Editorial: Harnessing chemotherapy resistance and development of novel therapeutic strategies for acute leukemia with KMT2A (MLL)-gene rearrangements. | Esposito, MT., et al. 2022. Front Pharmacol. 13: 977741. PMID: 36003510
Inhibitor of:
SF.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SID 7969543, 10 mg | sc-204278 | 10 mg | $139.00 | |||
SID 7969543, 50 mg | sc-204278A | 50 mg | $585.00 |