Sialyl Lewis x, Sodium Salt (CAS 98603-84-0)

Sialyl Lewis x, Sodium Salt, is a carbohydrate antigen found on the surface of cells, particularly leukocytes and endothelial cells, and plays a crucial role in cell adhesion and migration processes in the immune system. It is a sialylated carbohydrate structure with the terminal trisaccharide motif Neu5Acα2-3Galβ1-4[Fucα1-3]GlcNAc, where Neu5Ac represents N-acetylneuraminic acid, Gal is galactose, Fuc is fucose, and GlcNAc is N-acetylglucosamine. Sialyl Lewis x mediates interactions between selectins and their ligands, such as E-selectin (CD62E) expressed on endothelial cells, and is involved in the initial tethering and rolling of leukocytes on the endothelial surface during inflammation and immune responses. This interaction is crucial for the recruitment of leukocytes to sites of infection or tissue damage. In research, Sialyl Lewis x is utilized as a molecular probe to study cell adhesion mechanisms, inflammation, and metastasis in various biological contexts. Additionally, it serves as a target for developing diagnostic tools and interventions for inflammatory diseases, cancer metastasis, and other pathological conditions characterized by abnormal cell adhesion and migration. Moreover, the synthesis and modification of Sialyl Lewis x and its analogs are of interest for understanding structure-activity relationships and designing novel glycomimetic compounds with potential biomedical applications.