Sialyl Lewis a Antibody (121SLE): sc-51696

Sialyl Lewis a Antibody (121SLE) is a mouse monoclonal IgM antibody that detects Sialyl Lewis a protein of human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Sialyl Lewis a antibody (121SLE) is available as a non-conjugated format. Sialyl Lewis a protein plays a crucial role in cell adhesion and signaling, primarily functioning as a ligand for selectins, which are essential for leukocyte trafficking and inflammation. Sialyl Lewis a is predominantly located on the surface of cells, where Sialyl Lewis a contributes to the formation of a carbohydrate-rich microenvironment that facilitates cellular interactions. Expression of Sialyl Lewis a on the cell surface is vital for proper recruitment of immune cells to sites of injury or infection, thereby influencing immune response. Alterations in Sialyl Lewis a expression have been implicated in various pathological conditions, including cancer metastasis, making Sialyl Lewis a a significant marker for studying disease progression and therapeutic responses.

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Sialyl Lewis a Antibody (121SLE) References:

1. Expression and transcriptional regulation of the human alpha1, 3-fucosyltransferase 4 (FUT4) gene in myeloid and colon adenocarcinoma cell lines.  |  Taniguchi, A., et al. 2000. Biochem Biophys Res Commun. 273: 370-6. PMID: 10873613
2. P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils.  |  Huang, MC., et al. 2000. J Biol Chem. 275: 31353-60. PMID: 10882744
3. Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line.  |  Withers, DA. and Hakomori, SI. 2000. J Biol Chem. 275: 40588-93. PMID: 11006292
4. Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta 1 through a p38 mitogen-activated protein kinase-dependent pathway.  |  Wagers, AJ. and Kansas, GS. 2000. J Immunol. 165: 5011-6. PMID: 11046029
5. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV.  |  Nakayama, F., et al. 2001. J Biol Chem. 276: 16100-6. PMID: 11278338
6. Summary report on the ISOBM TD-6 workshop: analysis of 20 monoclonal antibodies against Sialyl Lewisa and related antigens. Montreux, Switzerland, September 19-24, 1997.  |  Rye, PD., et al. 1998. Tumour Biol. 19: 390-420. PMID: 9701730

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sialyl Lewis a Antibody (121SLE) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Sialyl Lewis a Antibody (121SLE) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sialyl Lewis a Antibody (121SLE) Specifications

Alternate Product Name: Sialyl Lewis a

Product Clone Name: 121SLE

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Sialyl Lewis a

Epitope Species: human

Product Reactivity/Detection: Sialyl Lewis a containing glycolipids

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Sialyl Lewis a Antibody (121SLE): N/A