Sialosyl Lewis a Antibody (B358): sc-59361

Sialosyl Lewis a Antibody (B358) is a mouse monoclonal IgM antibody that detects the Sialosyl Lewis a protein of human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Sialosyl Lewis a antibody (B358) is available as a non-conjugated format, which is crucial for research into various human cancers, including breast, pancreatic, stomach, and hematopoietic neoplasms. Sialosyl Lewis a (B358) monoclonal antibody plays a significant role in cell adhesion studies, particularly in cancer metastasis research, as Sialosyl Lewis a interacts with E-Selectin on endothelial cells, facilitating the adhesion of circulating tumor cells. This interaction is vital for the metastatic spread of cancer, making Sialosyl Lewis a an important biomarker for neoplastic transformation. Increased expression of Sialosyl Lewis a is often associated with a variety of carcinomas, indicating potential as a target for therapeutic intervention and diagnostic applications. Glycoproteins and gangliosides that present Sialosyl Lewis a structures can enhance cancer cell adhesion, underscoring Sialosyl Lewis a′s importance in cancer biology and clinical research.

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Sialosyl Lewis a Antibody (B358) References:

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2. Expression of Lewis(x), sialylated Lewis(x), Lewis(a), and sialylated Lewis(a) antigens in human lung carcinoma.  |  Fukushima, K. 1991. Tohoku J Exp Med. 163: 17-30. PMID: 1675497
3. The sialosyl Lewis a ganglioside is present in tumorigenic human urothelial cell lines.  |  Ugorski, M., et al. 1990. Int J Cancer. 45: 1204-9. PMID: 2190940
4. [Sialylated Lewis(x) and sialylated Lewis(a) as tumor-associated carbohydrate antigens in sera of patients with gastric cancer--usefulness of combination assay of these two antigens].  |  Nakagoe, T., et al. 1989. Nihon Shokakibyo Gakkai Zasshi. 86: 19-25. PMID: 2567361
5. [Lewis x and sialylated Lewis x-related antigen expression in cancerous and precancerous lesions of colon].  |  Yuan, M. 1987. Zhonghua Bing Li Xue Za Zhi. 16: 213-5, 40. PMID: 2964921
6. Sialylated Lewis(x) and Lewis(a) determinants expression on human neoplastic cell lines: immunocytometric study with the 5th workshop monoclonal antibodies.  |  Sedlák, J., et al. 1995. Neoplasma. 42: 49-52. PMID: 7542364
7. Role of sialosyl Lewis(a) in adhesion of colon cancer cells--the antisense RNA approach.  |  Kłopocki, AG., et al. 1998. Eur J Biochem. 253: 309-18. PMID: 9578490