SIAH-2 Antibody (22B9B5): sc-81788
- SIAH-2 Antibody (22B9B5) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against a synthetic peptide corresponding to a region near the N-terminus of SIAH of Drosophila melanogaster origin
- recommended for detection of SIAH-2 of human and Drosophila origin by WB, IF and IHC(P); also reactive with additional species, including porcine; non cross-reactive with SIAH-1 of human origin
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SIAH-2 Antibody (22B9B5). This work is in progress.
SIAH-2 Antibody (22B9B5) is a mouse monoclonal IgG1 antibody that detects SIAH-2 in human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. SIAH-2, or seven in absentia homolog 2, is a crucial E3 ubiquitin ligase that plays a significant role in regulating protein degradation via the ubiquitin-proteasome pathway. This 324 amino acid protein is vital for cellular responses to stress, particularly under hypoxic conditions, where SIAH-2 targets key proteins like HIF-1α prolyl hydroxylase 3 (PHD3) for degradation, thereby modulating the hypoxic response. SIAH-2′s ability to regulate the degradation of TRAF2, a protein involved in stress signaling and cytokine responses, highlights SIAH-2′s importance in maintaining cellular homeostasis and preventing excessive inflammatory responses. Notably, SIAH-2 null mice exhibit impaired respiratory responses and reduced hemoglobin levels when subjected to hypoxia, underscoring SIAH-2′s essential role in oxygen sensing and adaptation. Anti-SIAH-2 antibody (22B9B5) is an invaluable tool for researchers studying the intricate mechanisms of cellular stress responses and protein regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SIAH-2 Antibody (22B9B5) | sc-81788 | 200 µg/ml | $322.00 |