Date published: 2026-4-12

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Shz-1 (CAS 326886-05-9)

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Alternate Names:
2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide benzenesulfonic acid
Application:
Shz-1 is a potent inducer of Nkx2.5
CAS Number:
326886-05-9
Purity:
≥95%
Molecular Weight:
355.2
Molecular Formula:
C13H11BrN2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Shz-1, a chemical compound of interest in scientific research, has been studied extensively for its potential as an inhibitor of protein-protein interactions involved in cellular signaling pathways. Its mechanism of action involves disrupting specific protein-protein interactions critical for the activation of signaling cascades. Through this mechanism, Shz-1 interferes with the assembly of protein complexes necessary for the transmission of extracellular signals to intracellular effectors, thereby modulating downstream cellular responses. Research utilizing Shz-1 has provided insights into the role of protein-protein interactions in diverse cellular processes such as cell proliferation, differentiation, migration, and survival. Studies have employed Shz-1 to investigate the impact of inhibiting specific protein-protein interactions on signaling pathways implicated in development, tissue homeostasis, and disease pathogenesis. Furthermore, Shz-1 has been utilized as a tool compound in experimental models to explore the potential of targeting aberrant protein-protein interactions in diseases such as cancer, neurodegenerative disorders, and immune-mediated conditions. Additionally, Shz-1 serves as a valuable tool in elucidating the molecular mechanisms underlying protein-protein interactions and identifying potential targets for pharmacological intervention. Overall, Shz-1 represents a promising avenue for further research into the regulation of cellular signaling networks and the development of novel strategies.


Shz-1 (CAS 326886-05-9) References

  1. Overexpression of proenkephalin in the amygdala potentiates the anxiolytic effects of benzodiazepines.  |  Kang, W., et al. 2000. Neuropsychopharmacology. 22: 77-88. PMID: 10633493
  2. Synthetic sulfonyl-hydrazone-1 positively regulates cardiomyogenic microRNA expression and cardiomyocyte differentiation of induced pluripotent stem cells.  |  Quattrocelli, M., et al. 2011. J Cell Biochem. 112: 2006-14. PMID: 21445862
  3. Gene therapy for trigeminal pain in mice.  |  Tzabazis, AZ., et al. 2014. Gene Ther. 21: 422-6. PMID: 24572785
  4. Expression of sarcomeric tropomyosin in striated muscles in axolotl treated with shz-1, a small cardiogenic molecule.  |  Nan, C., et al. 2015. Cardiovasc Toxicol. 15: 29-40. PMID: 24958154

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Shz-1, 1 mg

sc-364137
1 mg
$67.00

Shz-1, 5 mg

sc-364137A
5 mg
$279.00