SHIP-1 Antibody (F-5): sc-271426

SHIP-1 Antibody (F-5) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect SHIP-1, also known as INPP5D, across mouse, rat, and human species. SHIP-1 is a crucial inositol phosphate 5-phosphatase characterized by its distinctive structure, which includes two phosphotyrosine-binding domains (PTB), a unique N-terminal SH2 domain, a proline-rich region, and two highly conserved motifs found in inositol phosphate 5-phosphatases. This structural configuration enables SHIP-1 to effectively regulate the PI3K signaling pathway by dephosphorylating PIP3 to PIP2, thereby modulating essential cellular processes such as immune cell activation, proliferation, and survival. Anti-SHIP-1 antibody (F-5) specifically targets the N-terminal epitope of SHIP-1, encompassing amino acids 1-105, ensuring high specificity and reliable performance in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). By facilitating accurate detection of SHIP-1 p145 across multiple species, SHIP-1 monoclonal antibody (F-5) serves as an invaluable tool for researchers investigating signal transduction, hematopoiesis, and immune responses. Understanding the detailed structure of SHIP-1 is vital for elucidating its role in maintaining immune homeostasis and its implications in diseases such as autoimmune disorders and cancer. Whether used in basic research or applied experimental settings, anti-SHIP-1 antibody (F-5) provides consistent and precise results, supporting comprehensive studies of SHIP-1 mediated pathways and interactions within the cellular environment. SHIP-1 monoclonal antibody (F-5) is essential for advancing the understanding of SHIP-1′s function and regulation, ultimately contributing to the development of targeted therapeutic strategies.

The preferred SHIP-1 antibody is SHIP-1 Antibody (P1C1): sc-8425.