SH3RF2 Antibody (Y-18): sc-100976

SH3RF2 Antibody (Y-18) is a mouse monoclonal IgG2a kappa light chain antibody that detects SH3RF2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SH3RF2 antibody (Y-18) is available as a non-conjugated format. SH3RF2, also known as RNF158, is a 729 amino acid protein characterized by one RING-type zinc finger domain and three SH3 domains, which play crucial roles in cellular signaling and protein interactions. The presence of the RING-type zinc finger motif, a conserved cysteine-rich domain capable of binding two zinc atoms, indicates SH3RF2′s involvement in the ubiquitination pathway, a vital mechanism for protein degradation and regulation within cells. SH3RF2 functions as an E3 ubiquitin-protein ligase, facilitating ubiquitin transfer from an E2 ubiquitin-conjugating enzyme to target proteins, marking these proteins for degradation. This regulatory function maintains cellular homeostasis and responds to stress signals, making SH3RF2 a key player in various biological processes. Due to alternative splicing, SH3RF2 exists in two different isoforms, which may have distinct functional roles in cellular contexts.

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SH3RF2 Antibody (Y-18) References:

1. Complete sequencing and characterization of 21,243 full-length human cDNAs.  |  Ota, T., et al. 2004. Nat Genet. 36: 40-5. PMID: 14702039
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).  |  Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
3. Confirmation of region-specific patterns of gene expression in the human brain.  |  Ernst, C., et al. 2007. Neurogenetics. 8: 219-24. PMID: 17375343
4. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.  |  Wilhelm, M., et al. 2012. J Biol Chem. 287: 2247-56. PMID: 22128169
5. SH3RF2 functions as an oncogene by mediating PAK4 protein stability.  |  Kim, TW., et al. 2014. Carcinogenesis. 35: 624-34. PMID: 24130170
6. Sh3rf2 Haploinsufficiency Leads to Unilateral Neuronal Development Deficits and Autistic-Like Behaviors in Mice.  |  Wang, S., et al. 2018. Cell Rep. 25: 2963-2971.e6. PMID: 30540932
7. Assessing the role of SH3RF1 and SH3RF2 polymorphisms in susceptibility to tuberculosis: A case-control study in the Han Chinese population.  |  Chen, H., et al. 2021. Microb Pathog. 152: 104567. PMID: 33129950
8. Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for NAFLD.  |  Yang, X., et al. 2021. Hepatology. 74: 1319-1338. PMID: 33894019
9. Identification of the Antigens Recognised by Colorectal Cancer Patients Using Sera from Patients Who Exhibit a Crohn's-like Lymphoid Reaction.  |  Boncheva, VB., et al. 2022. Biomolecules. 12: PMID: 36008952
10. Tet2 acts in the lateral habenula to regulate social preference in mice.  |  Xu, X., et al. 2023. Cell Rep. 42: 112695. PMID: 37402169
11. Identification and validation of prognostic signature genes of bladder cancer by integrating methylation and transcriptomic analysis.  |  Chatterjee, D., et al. 2024. Sci Rep. 14: 368. PMID: 38172584
12. SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation.  |  Gong, TT., et al. 2024. Commun Biol. 7: 67. PMID: 38195842

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SH3RF2 Antibody (Y-18) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SH3RF2 Antibody (Y-18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SH3RF2 Antibody (Y-18) Specifications

Alternate Product Name: SH3RF2

Product Clone Name: Y-18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 640-730

Epitope Target: SH3RF2

Epitope Species: human

Product Reactivity/Detection: SH3RF2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SH3RF2 Antibody (Y-18): N/A