Molecular structure of SH-6
SH-6 (CAS 701976-55-8)
See product citations (8)
Alternate Names:
Akt Inhibitor III
Application:
SH-6 is an inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1
CAS Number:
701976-55-8
Purity:
≥98%
Molecular Weight:
568.73
Molecular Formula:
C28H57O9P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SH-6 is an inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras (such as MAPK). Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.
SH-6 (CAS 701976-55-8) References
- Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. | Kozikowski, AP., et al. 2003. J Am Chem Soc. 125: 1144-5. PMID: 12553797
- Novel 2'-substituted, 3'-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway. | Tabellini, G., et al. 2004. Br J Haematol. 126: 574-82. PMID: 15287952
- TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation. | Puduvalli, VK., et al. 2005. Apoptosis. 10: 233-43. PMID: 15711939
- Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth. | Frogne, T., et al. 2005. Endocr Relat Cancer. 12: 599-614. PMID: 16172194
- Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. | Van Meter, TE., et al. 2006. Cancer. 107: 2446-54. PMID: 17041888
- The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. | Yin, H., et al. 2008. Blood. 111: 658-65. PMID: 17914025
- Expression of signaling mediators downstream of EGF-receptor predict sensitivity to small molecule inhibitors directed against the EGF-receptor pathway. | Sos, ML., et al. 2008. J Thorac Oncol. 3: 170-3. PMID: 18303439
- Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. | Gallia, GL., et al. 2009. Mol Cancer Ther. 8: 386-93. PMID: 19208828
- Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways. | Ghayad, SE., et al. 2010. Int J Cancer. 126: 545-62. PMID: 19609946
- Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. | Jiang, H., et al. 2009. J Exp Ther Oncol. 8: 25-33. PMID: 19827268
- Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations. | Krech, T., et al. 2010. BMC Cancer. 10: 287. PMID: 20546605
- Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells. | Chang, T., et al. 2011. FASEB J. 25: 1746-57. PMID: 21321187
- Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. | Chow, SE., et al. 2012. J Cell Biochem. 113: 3476-85. PMID: 22689083
Inhibitor of:
Akt, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SH-6, 0.5 mg | sc-205974 | 0.5 mg | $466.00 | |||
SH-6, 1 mg | sc-205974A | 1 mg | $818.00 |