Date published: 2026-4-30

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SGI-1776 (CAS 1025065-69-3)

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Alternate Names:
SGI-1776 free base
Application:
SGI-1776 is a potent apoptotic that targets Pim and FLT3 in AML and CLL cells
CAS Number:
1025065-69-3
Purity:
≥98%
Molecular Weight:
405.42
Molecular Formula:
C20H22F3N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SGI-1776 potently targets FLT3 (IC50 = 44nM). Treatment of AML and CLL cells with SGI-1776 causes induction of apoptosis. Importantly, SGI-1776 is also cytotoxic (IC50 of 3.1 mM) in AML primary cells, regardless of the FLT3 mutation status, which results in Mcl-1 protein decline. SGI-1776 inhibits tumor growth for intermediate EFS T/C activity in 1 of 39 evaluable models.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SGI-1776, 5 mg

sc-364615
5 mg
$158.00

SGI-1776, 50 mg

sc-364615A
50 mg
$1009.00