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SGI-1776 potently targets FLT3 (IC50 = 44nM). Treatment of AML and CLL cells with SGI-1776 causes induction of apoptosis. Importantly, SGI-1776 is also cytotoxic (IC50 of 3.1 mM) in AML primary cells, regardless of the FLT3 mutation status, which results in Mcl-1 protein decline. SGI-1776 inhibits tumor growth for intermediate EFS T/C activity in 1 of 39 evaluable models.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SGI-1776, 5 mg | sc-364615 | 5 mg | $158.00 | |||
SGI-1776, 50 mg | sc-364615A | 50 mg | $1009.00 |