Molecular structure of SGC707, CAS Number: 1687736-54-4
SGC707 (CAS 1687736-54-4)
Alternate Names:
N-6-isoquinolinyl-N′-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea
CAS Number:
1687736-54-4
Molecular Weight:
298.3
Molecular Formula:
C16H18N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SGC707 (CAS 1687736-54-4) References
- Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice. | Hoekstra, M., et al. 2019. Biochim Biophys Acta Mol Basis Dis. 1865: 1402-1409. PMID: 30776415
- Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer. | Hsu, MC., et al. 2019. J Hematol Oncol. 12: 79. PMID: 31324208
- Asymmetrical methyltransferase PRMT3 regulates human mesenchymal stem cell osteogenesis via miR-3648. | Min, Z., et al. 2019. Cell Death Dis. 10: 581. PMID: 31378783
- Decreased nitric oxide content mediated by asymmetrical dimethylarginine and protein l-arginine methyltransferase 3 in macrophages induces trophoblast apoptosis: a potential cause of recurrent miscarriage. | Hao, F., et al. 2021. Hum Reprod. 36: 3049-3061. PMID: 34647126
- PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. | de Jong, LM., et al. 2022. Sci Rep. 12: 483. PMID: 35013582
- PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism. | Liao, Y., et al. 2022. Cell Death Dis. 13: 943. PMID: 36351894
- PRMT3 regulates the progression of invasive micropapillary carcinoma of the breast. | Zhi, R., et al. 2023. Cancer Sci. 114: 1912-1928. PMID: 36637351
- PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer. | Shi, Y., et al. 2023. Nat Commun. 14: 1932. PMID: 37024475
- The impact of early pregnancy metabolic disorders on pregnancy outcome and the specific mechanism. | Zhu, XZ., et al. 2023. Eur J Med Res. 28: 197. PMID: 37355665
- Asymmetric arginine dimethylation of cytosolic RNA and DNA sensors by PRMT3 attenuates antiviral innate immunity. | Zhu, J., et al. 2023. Proc Natl Acad Sci U S A. 120: e2214956120. PMID: 37639603
- PRMT3-Mediated Arginine Methylation of METTL14 Promotes Malignant Progression and Treatment Resistance in Endometrial Carcinoma. | Wang, Y., et al. 2023. Adv Sci (Weinh). 10: e2303812. PMID: 37973560
- PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease. | Zhou, G., et al. 2024. Mol Med. 30: 8. PMID: 38200452
- A-Z of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer. | Mohan, N., et al. 2024. Cancers (Basel). 16: PMID: 38539439
Inhibitor of:
AI931714, CARM1, DOT1L1, L3MBTL3, Mnt, Monomethyl Arg Symmetric, NSD1, PRA1, PRMT10, PRMT2, PRMT5, PRMT6, SETD6, and Trimethyl Histone H3.Activator of:
C11orf41_D430041D05Rik, and ZCWPW1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SGC707, 1 mg | sc-507461 | 1 mg | $48.00 |