SFRS17A Antibody (FE-06): sc-101139
- SFRS17A Antibody (FE-06) is a mouse monoclonal IgG2b κ SFRS17A antibody provided at 100 µg/ml
- raised against recombinant SFRS17A of human origin
- recommended for detection of SFRS17A of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SFRS17A Antibody (FE-06). This work is in progress.
SFRS17A Antibody (FE-06) is a mouse monoclonal IgG2b kappa light chain antibody that detects SFRS17A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SFRS17A antibody (FE-06) is available as a non-conjugated format. SFRS17A protein, also known as splicing factor, arginine/serine-rich 17A, XE7, 721P, XE7Y, CCDC133, CXYorf3, or DXYS155E, is a 695 amino acid protein characterized by the presence of one RNA recognition motif (RRM) domain, which is crucial for RNA processing. SFRS17A predominantly localizes to nuclear speckles, which are essential for the assembly and modification of spliceosomal components. SFRS17A is widely expressed across various tissues, with highest levels found in lung, heart, brain, liver, kidney, pancreas, skeletal muscle, placenta, and activated B-cells. As a vital subunit of the spliceosome, SFRS17A plays a significant role in regulating alternative splice site selection for diverse mRNA precursors, thereby influencing gene expression and protein diversity. Additionally, SFRS17A can function as a monomer, interacting with other proteins such as ZNF265 and SF2/ASF, both integral to pre-mRNA splicing and transcriptional regulation. Notably, due to alternative splicing events, SFRS17A is expressed in three different isoforms, further underscoring its complexity and importance in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SFRS17A Antibody (FE-06) References:
- Structure and expression of the human pseudoautosomal gene XE7. | Ellison, JW., et al. 1992. Hum Mol Genet. 1: 691-6. PMID: 1302606
- Directed isolation of human genes that escape X inactivation. | Ellison, J., et al. 1992. Somat Cell Mol Genet. 18: 259-68. PMID: 1496421
- XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. | Mangs, AH., et al. 2006. Nucleic Acids Res. 34: 4976-86. PMID: 16982639
- ZRANB2: structural and functional insights into a novel splicing protein. | Mangs, AH. and Morris, BJ. 2008. Int J Biochem Cell Biol. 40: 2353-7. PMID: 17905639
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SFRS17A Antibody (FE-06) | sc-101139 | 100 µg/ml | $339.00 |