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A cell permeable suppressor of FK506 1, which, in high salt media, reverses the inhibition of cell growth by FK506. It interacts with Por1p (YVDAC1) channel protein in the outer mitochondrial membrane. The compound perturbs ion homeostasis and induces hyperpolarization of the inner mitochondrial membrane and mitochondria-dependent cell death with ROS (reactive oxygen species) production in a low NaCl growth media. It also induces expression of calcineurin targeted genes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SFK1, 10 mg | sc-215849 | 10 mg | $159.00 |