Molecular structure of SF 11, CAS Number: 443292-81-7
SF 11 (CAS 443292-81-7)
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Alternate Names:
N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
Application:
SF 11 is a NPY2-R antagonist
CAS Number:
443292-81-7
Molecular Weight:
446.6
Molecular Formula:
C27H30N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
An NPY Y2 antagonist (IC50 = 199 nM). Displays no affinity for Y1 receptor at concentrations up to 35 μM. Shown to cause significant lethality in mice. Brain penetrant.
SF 11 (CAS 443292-81-7) References
- Estimation of utilities for the effects of depression from the SF-12. | Lenert, LA., et al. 2000. Med Care. 38: 763-70. PMID: 10901359
- A novel antifungal pyrrole derivative from Datura metel leaves. | Dabur, R., et al. 2004. Pharmazie. 59: 568-70. PMID: 15296098
- Screening and analyzing the potential bioactive components from Shaofu Zhuyu decoction, using human umbilical vein endothelial cell extraction and high-performance liquid chromatography coupled with mass spectrometry. | Su, SL., et al. 2008. Biomed Chromatogr. 22: 1385-92. PMID: 18655214
- Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. | Brothers, SP., et al. 2010. Mol Pharmacol. 77: 46-57. PMID: 19837904
- Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. | Mittapalli, GK., et al. 2012. Bioorg Med Chem Lett. 22: 3916-20. PMID: 22607676
- Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. | Domin, H., et al. 2019. ACS Chem Neurosci. 10: 3454-3463. PMID: 31267743
- Neuropeptide Y Y2 and Y5 receptors as potential targets for neuroprotective and antidepressant therapies: Evidence from preclinical studies. | Domin, H. 2021. Prog Neuropsychopharmacol Biol Psychiatry. 111: 110349. PMID: 33991587
- The antidepressant-like and glioprotective effects of the Y2 receptor antagonist SF-11 in the astroglial degeneration model of depression in rats: Involvement of glutamatergic inhibition. | Domin, H., et al. 2024. Behav Brain Res. 457: 114729. PMID: 37871655
- Realization of antireflection elements using glass-based photonic crystal structures | Amiri, I. S., Jafar A. Alzubi, S. K. Tripathy, and G. Palai. 2019. Optik. 199: 163386.
Inhibitor of:
NPY2-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SF 11, 5 mg | sc-311535 | 5 mg | $105.00 | |||
SF 11, 25 mg | sc-311535A | 25 mg | $425.00 |