Molecular structure of SEW2871, CAS Number: 256414-75-2
SEW2871 (CAS 256414-75-2)
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Application:
SEW2871 is a potent selective EDG-1 inhibitor
CAS Number:
256414-75-2
Purity:
>98%
Molecular Weight:
440.36
Molecular Formula:
C20H10F6N2OS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SEW2871 is a small molecule selective agonist of EDG-1 (Sphingosine-1-phosphate receptor 1 S1P1), a protein involved in signaling and regulation of heart rate, coronary artery caliber, and lymphocyte recirculation. SEW2871 has been used as a tool for investigating the role of the EDG-1 receptor in cardiovascular regulation, and specifically for its role in ischemia/reperfusion injury. An antiinflammatory behavior is produced by SEW2871 activation of the EDG-1 receptor, showing an inhibition of monocyte adhesion to endothelial cells upon this activation.
SEW2871 (CAS 256414-75-2) References
- Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. | Kluk, MJ. and Hla, T. 2002. Biochim Biophys Acta. 1582: 72-80. PMID: 12069812
- Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. | Sanna, MG., et al. 2004. J Biol Chem. 279: 13839-48. PMID: 14732717
- A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. | Hale, JJ., et al. 2004. J Med Chem. 47: 6662-5. PMID: 15615513
- Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. | Bolick, DT., et al. 2005. Arterioscler Thromb Vasc Biol. 25: 976-81. PMID: 15761190
- Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. | Whetzel, AM., et al. 2006. Circ Res. 99: 731-9. PMID: 16960101
- S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias. | Tsukada, YT., et al. 2007. J Cardiovasc Pharmacol. 50: 660-9. PMID: 18091583
- Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice. | Dong, J., et al. 2014. Clin Exp Immunol. 177: 94-101. PMID: 24611843
- SEW2871 protects from experimental colitis through reduced epithelial cell apoptosis and improved barrier function in interleukin-10 gene-deficient mice. | Dong, J., et al. 2015. Immunol Res. 61: 303-11. PMID: 25588868
- Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice. | Ni, Q., et al. 2015. Int Immunopharmacol. 26: 37-42. PMID: 25776899
- Activation of sphingosine 1-phosphate receptor-1 by SEW2871 improves cognitive function in Alzheimer's disease model rats. | Asle-Rousta, M., et al. 2013. EXCLI J. 12: 449-61. PMID: 26417237
- The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. | St-Cyr Giguère, F., et al. 2017. Brain Res. 1658: 51-59. PMID: 28104351
- Sphingosine-1-Phosphate Receptor-1 Agonist Sew2871 Causes Severe Cardiac Side Effects and Does Not Improve Microvascular Barrier Breakdown in Sepsis. | Flemming, S., et al. 2018. Shock. 49: 71-81. PMID: 28538086
- Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver. | Yang, T., et al. 2020. Toxicol Lett. 331: 242-253. PMID: 32579994
- The S1PR1 agonist SEW2871 promotes the survival of skin flap. | Zhang, D., et al. 2021. Can J Physiol Pharmacol. 99: 1280-1287. PMID: 34310896
- S1P analogues SEW2871, BAF312 and FTY720 affect human Th17 and Treg generation ex vivo. | Zehra Okus, F., et al. 2022. Int Immunopharmacol. 107: 108665. PMID: 35255303
Inhibitor of:
EDG-1, MFSD2B, Septin, SPHKAP, and SYDE2.Activator of:
ACP6, EDG-1, EDG-2, EDG-5, EDG-6, EDG-8, LASS5, NKG2-D, PSAPL1, SK2, SO, SPNS1, and Ypk2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SEW2871, 5 mg | sc-203251 | 5 mg | $38.00 | |||
SEW2871, 10 mg | sc-203251A | 10 mg | $53.00 |